Table 3

cardiovascular co-morbidities in patients with PsA

StudyType of studyComparison groupSubjects; total number (ascertainment procedures); gender distribution; age, yearsTime periodStatistical analysesFindings
Han18Cross-sectional study; patient source: PharMetrics Patient-Centric Database, USAFour matched controls: sex, age, geographical region, previous length of time in plan3066 PsA patients (ICD-9);49.7±11.2 years2001–2Age and sex adjusted prevalences of comorbidities; the prevalence ratios were estimated by Cochran–Mantel–Haenszel methodIncreased prevalence of:* ischaemic heart disease (7.3%); peripheral vascular disease (2.9%); congestive heart failure (1.9%); cerebrovascular disease (3.1%)
Gladman17Prospective cohortCanadian Community Health Survey648 PsA patients (inflammatory arthritis associated with psoriasis); 56% male; 43.5 years1978–2004Cross-sectional examination with age and gender matched groups; SPR were calculated; Cox relative risk regression analysisIncreased SPR:* angina (SPR 1.97); myocardial infarction (SPR 2.57)
Jamnitski19Single-centre studyComparison with 353 RA patients43489 PsA patients aged between 50 and 75 years (according to Moll and Wright criteria)2010Logistic regression analysisCardiovascular disease defined as a history of myocardial infarction and/or stroke and/or transient ischaemic attack; prevalence of cardiovascular disease in PsA was 10% compared to 12% in RA; OR 0.78; 95% CI 0.51 to 1.20, p=0.26; also age and sex stratified OR were not different between RA and PsA
Ahlehoff7Population-based studyGeneral population of Denmark (n=4 003 265)607 PsA patients (ICD-8 and 10); age and gender distribution of PsA patients are lacking1997–2006RR and 95% CI; Poisson regression models; confounders: age, calendar year, concomitant medication use, comorbidity, socioeconomic data, genderIncreased cardiovascular risk in PsA patients; RR 1.79; 95% CI 1.31 to 2.45†

  • ↵* All p<0.05.

  • ↵† Composite rate ratio (RR) of myocardial infarction, stoke and cardiovascular death is presented.

  • ICD-8, 9 and 10, International Classification of Diseases 8th, 9th and 10th revision; PsA, psoriatic arthritis; RA, rheumatoid arthritis; SPR, standardised prevalence ratio.