Table 3

Representative genes with more than one differentially methylated loci

RA status	Gene	Differentially methylated loci	Total loci on array	p Value for enrichment	Enrichment factor
Hypo	RHOJ	2	9	2.16E-05	525.33
Hypo	MEFV	2	11	9.64E-05	200.66
Hypo	CD93	3	15	2.44E-06	200.26
Hypo	MYEF2	2	13	0.0001139	169.79
Hypo	ITGA4	3	18	4.52E-06	157.79
Hypo	P2RY6	2	21	0.0001567	142.51
Hypo	AXIN2	2	37	0.0002877	102.35
Hypo	COL22A1	3	36	2.26E-05	83.44
Hypo	COL1A1	4	41	1.26E-06	79.55
Hypo	COL6A1	2	33	0.0006962	60.68
Hypo	ST14	2	43	0.0009217	51.33
Hypo	SYNJ2	2	68	0.0026518	27.84
Hyper	IGSF6	3	6	1.21E-06	275.53
Hyper	EGF	2	13	0.0003606	107.08
Hyper	ITGB8	2	13	0.0005041	84.78
Hyper	TNF	4	27	2.66E-06	71.05
Hyper	AKT3	2	30	0.0008412	63.26
Hyper	MAP3K1	2	24	0.0013940	45.92
Hyper	PLXNA2	3	45	0.0001585	43.66
Hyper	TRERF1	4	50	1.49E-05	41.35
Hyper	FOXO1	2	32	0.0020262	36.94
Hyper	TIMP2	4	64	5.67E-05	28.37
Hyper	COL4A1	2	71	0.0035030	26.73
Hyper	COL4A2	5	139	1.53E-05	22.99
Hyper	SRPK2	2	45	0.0056023	20.18
Hyper	ADAM12	2	52	0.0057208	19.88
Hyper	PTPN14	2	59	0.0080113	16.26
Hyper	DNMT3A	2	77	0.0088166	15.35
Hyper	CREB5	2	82	0.0142486	11.7
Hyper	PRKCZ	2	263	0.0332803	7.22