Reasons for switching
| Switch to a second agent (n=80) | Switch to a third agent (n=22) | |
|---|---|---|
| Ineffectiveness: primary | 26 (33) | 12 (55) |
| Partial effect/loss of response | 32 (40) | 3 (14) |
| Adverse events/intolerance | 11 (14) | 5 (23) |
| Inflammatory bowel disease | 5 | – |
| Urosepsis | 1 | – |
| Chest pain, dyspnoea, air trapping lung | 1 | – |
| Injection site reaction/fear of injections | 1 | 4 |
| Other | 3 | 1 |
| Combination ineffectiveness and adverse events | 1 (1) | – |
| Uveitis | 8 (10) | 1 (5) |
| Non-compliance | 2 (3) | – |
| Unknown | – | 1 (5) |