ORs for disease risk in different subsets of rheumatoid arthritis in subjects exposed to different combinations of HLA-DRB1 shared epitope (SE) and smoking compared with non-exposed subjects
| CEP-1/Cit-vim/Cit-C1 | HLA-DBR1 SE | Smoking | Cases/controls | OR* | 95% CI |
|---|---|---|---|---|---|
| −/−/− | − | − | 115/228 | 1 | Ref |
| −/−/− | + | − | 176/244 | 1.4 | 1.1 to 1.9 |
| −/−/− | − | + | 173/316 | 1.1 | 0.8 to 1.5 |
| −/−/− | + | + | 233/315 | 1.6 | 1.2 to 2.1 |
| +/−/− | − | − | 3/228 | 1 | Ref |
| +/−/− | + | − | 25/244 | 8 | 2.4 to 27.0 |
| +/−/− | − | + | 13/316 | 3.3 | 0.9 to 11.9 |
| +/−/− | + | + | 46/315 | 12.5 | 3.8 to 40.9 |
| −/+/− | − | − | 7/228 | 1 | Ref |
| −/+/− | + | − | 42/244 | 5.8 | 2.5 to 13.3 |
| −/+/− | − | + | 15/316 | 1.7 | 0.7 to 4.3 |
| −/+/− | + | + | 64/315 | 7.3 | 3.2 to 16.4 |
| −/−/+ | − | − | 35/228 | 1 | Ref |
| −/−/+ | + | − | 41/244 | 1.1 | 0.7 to 1.8 |
| −/−/+ | − | + | 31/316 | 0.6 | 0.4 to 1.1 |
| −/−/+ | + | + | 68/315 | 1.4 | 0.9 to 2.3 |
| +/+/− | − | − | 5/228 | 1 | Ref |
| +/+/− | + | − | 29/244 | 5.5 | 2.1 to 14.5 |
| +/+/− | − | + | 7/316 | 1 | 0.3 to 3.3 |
| +/+/− | + | + | 118/315 | 18.4 | 7.3 to 46.1 |
| +/−/+ | − | − | 3/228 | 1 | Ref |
| +/−/+ | + | − | 25/244 | 7.7 | 2.3 to 26.1 |
| +/−/+ | − | + | 11/316 | 2.7 | 0.7 to 10.0 |
| +/−/+ | + | + | 65/315 | 17.2 | 5.3 to 55.8 |
| −/+/+ | − | − | 7/228 | 1 | Ref |
| −/+/+ | + | − | 27/244 | 3.5 | 1.5 to 8.4 |
| −/+/+ | − | + | 10/316 | 1 | 0.4 to 2.8 |
| −/+/+ | + | + | 52/315 | 5.6 | 2.5 to 12.7 |
| +/+/+ | − | − | 6/228 | 1 | Ref |
| +/+/+ | + | − | 54/244 | 8.5 | 3.6 to 20.1 |
| +/+/+ | − | + | 14/316 | 1.6 | 0.6 to 4.3 |
| +/+/+ | + | + | 189/315 | 23.3 | 10.1 to 53.7 |
↵* Adjusted for age, gender and residential area.