Table 1

Dosing Information for tocilizumab

EMA area*FDA areaJapan*
RA8 mg/kg every 4 weeks4 mg/kg every 4 weeks initially, with increase to 8 mg/kg every 4 weeks if clinically indicated8 mg/kg every 4 weeks
Polyarticular JIA8 mg/kg every 4 weeks
Systemic onset JIA12 mg/kg body weight every 2 weeks in children with body weight <30 kg
8 mg/kg body weight every 2 weeks in children with body weight >30 kg
8 mg/kg every 2 weeks (interval may be decreased to weekly)
Multicentric Castleman's disease8 mg/kg every 2 weeks (interval may be decreased to weekly)
  • *In the EMA area and Japan, it can also be used as monotherapy in patients with contraindications to or intolerant of methotrexate.

  • EMA, European Medicines Agency; JIA, juvenile idiopathic arthritis; MTX, methotrexate; RA, rheumatoid arthritis; TCZ, tocilizumab.