Characteristics of the statin use and statin non-use samples (n=2207)
| Statin users (n=448) | Non-users (n=1759) | ||
|---|---|---|---|
| Means (SD) or n(%) | Means (SD) or n(%) | p Value* | |
| Age (years) | 62.5 (9.0) | 60.7 (9.3) | <0.001 |
| Female (%) | 248 (55.4) | 1062 (60.4) | 0.06 |
| Body mass index (kg/m2) | 29.8 (4.7) | 28.7 (4.9) | <0.001 |
| Hypertension (%) | 37 (8.3) | 83 (4.7) | 0.003 |
| Comorbidity | 0.46 (0.81) | 0.32 (0.79) | 0.001 |
| Smoker (%) | 40 (8.9) | 107 (6.1) | 0.03 |
| Education | |||
| Less than high school | 17 (3.8) | 58 (3.3) | 0.81 |
| High school diploma | 58 (13.1) | 219 (12.5) | |
| Some college | 367 (83.0) | 1469 (67.1) | |
| Kellgren-Lawrence (right, left) | |||
| 0 | 62 (14.1), 74 (16.6) | 242 (13.8), 306 (17.5) | 0.85, 0.36 |
| 1 | 110 (25.0), 100 (22.5) | 110 (25.0), 440 (25.1) | |
| 2 | 161 (36.6), 156 (35.1) | 684 (39.1), 629 (35.9) | |
| 3 | 89 (20.2), 100 (22.5) | 319 (18.2), 323 (18.4) | |
| 4 | 18 (4.1), 15 (3.4) | 70 (4.0), 53 (3.0) | |
| Summed KL grades† | |||
| Baseline | 3.3 (1.5) | 3.2 (1.5) | |
| 1-year | 3.5 (1.6) | 3.3 (1.5) | |
| 2-year | 3.6 (1.7) | 3.4 (1.6) | |
| 3-year | 3.6 (1.7) | 3.5 (1.6) | |
| 4-year | 3.7 (1.5) | 3.5 (1.6) | |
| 7-day pain rating (Mean, SD, n) | |||
| Baseline | 3.8 (2.7) 445 | 3.5 (2.7) 1742 | 0.01 |
| 1-year | 3.5 (2.8) 425 | 3.2 (2.9) 1696 | 0.04 |
| 2-year | 3.7 (3.0) 415 | 3.1 (2.8) 1628 | 0.001 |
| 3-year | 3.6 (2.9) 416 | 3.2 (2.8) 1595 | 0.005 |
| 4-year | 3.7 (3.0) 414 | 3.2 (2.9) 1587 | 0.002 |
| WOMAC Pain Scale (Mean, SD, n) | |||
| Baseline | 4.2 (3.9) 448 | 3.5 (3.8) 1758 | <0.001 |
| 1-year | 3.7 (3.9) 433 | 3.1 (3.6) 1718 | 0.001 |
| 2-year | 3.6 (3.8) 422 | 3.1 (3.5) 1646 | 0.02 |
| 3-year | 3.9 (4.1) 420 | 3.1 (3.6) 1622 | <0.001 |
| 4-year | 3.8 (4.0) 419 | 3.1 (3.6) 1613 | <0.001 |
| WOMAC Physical Function (Mean, SD, n) | |||
| Baseline | 13.2 (12.5) 447 | 10.9 (12.0) 1749 | <0.001 |
| 1-year | 11.0 (12.4) 430 | 9.6 (11.6) 1707 | 0.04 |
| 2-year | 10.7 (12.1) 413 | 9.2 (11.2) 1632 | 0.02 |
| 3-year | 12.3 (13.2) 414 | 9.3 (11.3) 1603 | <0.001 |
| 4-year | 11.7 (12.8) 413 | 9.6 (11.7) 1600 | 0.001 |
*p Values are based on independent sample t-tests for continuous variables and Pearson χ2 for categorical variables.
†The baseline sample size was n=404 statin users and n=1617 non-users.
KL, Kellgren-Lawrence.