Table 2

Radiological progression per subgroup

		All patients	All patients	p Value	Continuous treatment	On-demand treatment	p Value	Continuous treatment	On-demand treatment	p Value
Time-averaged determinant		Low	High		Low	Low		High	High
CRP	Number	46	97		21	25		52	45
	dmSASSS^* (SD)	0.8 (1.5)	0.9 (2.3)	0.71	0.9 (1.8)	0.8 (1.1)	0.62	0.2 (1.6)	1.7 (2.8)	0.003
	N_prog^†	12 (26%)	24 (25%)	0.97	5 (24%)	7 (28%)	0.97	7 (13%)	17 (38%)	0.011
ESR	Number	70	72		35	35		37	35
	dmSASSS^* (SD)	0.3 (2.0)	1.4 (2.1)	0.006	0.1 (1.8)	0.7 (2.2)	0.03	0.9 (1.6)	2.0 (2.4)	0.038
	N_prog^†	11 (16%)	25 (35%)	0.016	4 (11%)	7 (20%)	0.51	8 (22%)	17 (49%)	0.031
BASDAI	Number	108	42		58	50		18	24
	dmSASSS^* (SD)	1.0 (2.4)	0.7 (1.5)	0.45	0.5 (1.8)	1.6 (2.8)	0.015	0.1 (1.1)	1.1 (1.6)	0.021
	N_prog^†	30 (28%)	8 (19%)	0.37	11 (19%)	19 (38%)	0.047	1 (6%)	7 (29%)	0.126
ASDAS-CRP	Number	74	76		40	34		36	40
	dmSASSS^* (SD)	0.6 (2.0)	1.2 (2.3)	0.26	0.4 (2.0)	0.9 (2.1)	0.11	0.4 (1.2)	1.9 (2.7)	0.005
	N_prog^†	19 (26%)	19 (25%)	0.93	8 (20%)	11 (32%)	0.35	4 (11%)	15 (38%)	0.017
ASDAS-ESR	Number	83	67		46	37		30	37	0.006 0.012
	dmSASSS^* (SD)	0.7 (2.2)	1.2 (2.2)	0.32	0.4 (1.9)	1.1 (2.5)	0.097	0.4 (1.3)	1.8 (2.5)	0.006
	N_prog^†	20 (24%)	18 (27%)	0.84	9 (20%)	11 (30%)	0.41	3 (10%)	15 (41%)	0.012

↵* Mean (SD) value of δ modified stoke ankylosing spondylitis spine score (dmSASSS) in this (sub) group, defined as the difference between the modified Stoke Ankylosing Spondylitis Spine Score (mSASSS) at month 0 and month 24.
↵† Nprog is the number (percentage) of participants in this (sub) group with a progression score on the mSASSS of 2 or more.
ASDAS, ankylosing spondylitis disease activity score; BASDAI, Bath ankylosing spondylitis disease activity index; CRP, C reactive protein; ESR, erythrocyte sedimentation rate.