Changes from baseline in clinical variables at time of flare. Data for five patients were excluded because flare had been treated between study assessments
| Change at time of flare (n=19) | ||
|---|---|---|
| Variable | Median (IQR) | Mean (SD) |
| EMS | 15.00 (0.00 to 60.00) | 75.26 (175.20) |
| Fatigue VAS | 9.00 (0.00 to 35.00) | 14.16 (26.21) |
| Pain VAS | 25.00 (3.00 to 51.00) | 29.32 (26.68) |
| Patient global VAS | 17.00 (4.00 to 54.00) | 23.00 (25.33) |
| Physician global VAS | 12.00 (5.00 to 23.00) | 14.79 (11.94) |
| TJC | 1.00 (0.00 to 7.00) | 2.42 (6.99) |
| SJC | 1.00 (0.00 to 2.00) | 1.47 (5.18) |
| HAQ | 0.13 (−0.13 to 1.00) | 0.32 (0.66) |
| RAQoL | 1.00 (0.00 to 5.00) | 2.74 (4.37) |
| CRP* | 0.00 (0.00 to 8.25) | 7.56 (16.89) |
| ESR‡ | 4.00 (−0.50 to 13.00) | 7.35 (11.48) |
| DAS28-ESR | 0.78 (0.09 to 2.30) | 1.13 (1.46)† |
↵* n=18.
↵† DAS28-CRP imputed for two patients with missing ESR.
‡ n=17.
CRP, C reactive protein; DAS28, 28-joint count Disease Activity Score; EMS, early morning stiffness; ESR, erythrocyte sedimentation rate; HAQ, Health Assessment Questionnaire; RAQoL, Rheumatoid Arthritis Quality of Life Questionnaire score; SJC, swollen joint count; TJC, tender joint count; VAS, visual analogue scale.