Table 4

Allele–dose-dependent association of FGB −455G>A and FGA T312A genotype on plasma CRP levels: pooled analyses on RA as well as non-RA cohort

	CRP ≥10 mg/l
	FGB −455G>A^*		FGA T312A^†
	Crude	Pooled (M–H)	Crude	Pooled (M–H)
	OR (95% CI)	OR (95% CI)	OR (95% CI)	OR (95% CI)
Total
0 copy	1.0 (reference)	1.0 (reference)	1.0 (reference)	1.0 (reference)
1 copy	0.67 (0.56 to 0.82)	0.67 (0.55 to 0.82)	1.05 (0.87 to 1.26)	1.14 (0.94 to 1.38)
2 copies	0.50 (0.33 to 0.76)	0.46 (0.30 to 0.72)	0.91 (0.63 to 1.31)	1.13 (0.78 to 1.65)
p/p_adj trend	<10⁻⁵/0.001	<10⁻⁶/0.0006	1.0/1.0	0.23/0.40
p_BD	0.98		0.19
F13A 34VV
0 copy	1.0 (reference)	1.0 (reference)	1.0 (reference)	1.0 (reference)
1 copy	0.46 (0.35 to 0.61)	0.45 (0.34 to 0.61)	1.31 (1.01 to 1.70)	1.49 (1.14 to 1.96)
2 copies	0.25 (0.13 to 0.51)	0.26 (0.13 to 0.52)	1.64 (1.04 to 2.58)	2.11 (1.31 to 3.40)
p/p_adj trend	<10⁻¹⁰/<0.00002	<10⁻⁹/<0.00002	0.008/0.07	0.0001/0.009
p_BD	0.32		0.98
F13A 34L
0 copy	1.0 (reference)	1.0 (reference)	1.0 (reference)	1.0 (reference)
1 copy	1.01 (0.77 to 1.31)	1.02 (0.77 to 1.34)	0.83 (0.63 to 1.08)	0.83 (0.63 to 1.10)
2 copies	0.93 (0.54 to 1.58)	0.75 (0.42 to 1.32)	0.38 (0.19 to 0.75)	0.42 (0.20 to 0.85)
p/p_adj trend	0.88/0.92	0.59/0.70	<0.01/0.04	0.01/0.06
p_BD	0.08		0.25

Pooled analyses on RA (288 patients, 913 observation) and non-RA cohort (636 patients, 2541 observations). Crude as well as Mantel–Haenszel (M–H) point estimates of OR and 95% CI are given.
↵* p/p_adj for homogeneity (F13A 34VV vs F13A 34L) for FGB<10⁻⁵/=0.001.
↵† p/p_adj for homogeneity (F13A 34VV vs F13A 34L) for FGA=0.0001/=0.006.
CRP, C-reactive protein; F13A, factor XIIIA; FGA, α-fibrinogen; FGB, β-fibrinogen; p_adj, p value after adjustment for non-independent observations within clusters; p_BD, Breslow–Day testing for homogeneity of OR between both cohorts; RA, rheumatoid arthritis.