Interactive influence of FGB −455G>A and F13A V34L genotype on plasma CRP level in the non-RA cohort
| Carriage of FGB −455A versus FGB −455GG | ||||
|---|---|---|---|---|
| Univariate | Trend test | Multivariate | Trend test | |
| CRP (mg/l) | OR (95% CI) | p/padj* | OR (95% CI) | p/padj* |
| Total | ||||
| ≤5 | 1.0 (reference) | 1.0 (reference) | ||
| 5–10 | 0.74 (0.60 to 0.90) | 0.77 (0.62 to 0.94) | ||
| 10–15 | 0.71 (0.50 to 1.00) | 0.75 (0.53 to 1.06) | ||
| >15 | 0.52 (0.36 to 0.75) | <10−5/0.009 | 0.54 (0.37 to 0.78) | <0.0001/<0.02 |
| F13A 34VV | ||||
| ≤5 | 1.0 (reference) | 1.0 (reference) | ||
| 5–10 | 0.58 (0.45 to 0.77) | 0.61 (0.46 to 0.81) | ||
| 10–15 | 0.39 (0.24 to 0.64) | 0.41 (0.25 to 0.68) | ||
| >15 | 0.27 (0.16 to 0.46) | <10−10†/0.0001 | 0.28 (0.17 to 0.47) | <10−9‡/<0.0002 |
| F13A 34L | ||||
| ≤5 | 1.0 (reference) | 1.0 (reference) | ||
| 5–10 | 0.97 (0.72 to 1.32) | 0.99 (0.72 to 1.34) | ||
| 10–15 | 1.42 (0.86 to 2.35) | 1.45 (0.87 to 2.41) | ||
| >15 | 1.20 (0.69 to 2.10) | 0.29†/0.63 | 1.23 (0.70 to 2.17) | 0.35‡/0.56 |
Analyses based on 636 patients and 2541 observations. Results of univariate and multivariate analyses (adjusted for sex, age, pregnancy and ethnicity) as well as trend tests across ordinal CRP level categories are given.
↵* padj, p value after adjustment for non-independent observations within clusters.
↵† p for homogeneity (F13A 34VV vs F13A 34L)<10−6 (univariate).
↵‡ p for homogeneity (F13A 34VV vs F13A 34L)<10−6 (multivariate).
CRP, C-reactive protein; F13A, factor XIIIA; FGB, β-fibrinogen; RA, rheumatoid arthritis.