Table 2

Allele–dose-dependent association of FGB −455G>A genotype with CRP level in RA as well as non-RA patients

CRP ≥10 mg/l
FGB −455GGFGB −455GAFGB −455AATrend test
OR (reference)OR (95% CI)OR (95% CI)p/padj*
RA cohort
Total
 Univariate1.00.64 (0.48 to 0.86)0.52 (0.29 to 0.93)0.0007/<0.015
 Multivariate1.00.47 (0.30 to 0.74)0.47 (0.16 to 1.38)0.001/<0.03
F13A 34VV
 Univariate‡1.00.56 (0.36 to 0.86)0.28 (0.09 to 0.83)0.0008/<0.02
 Multivariate#1.00.36 (0.19 to 0.71)…†<0.0008/0.01
F13A 34L
 Univariate‡1.00.73 (0.48 to 1.09)0.71 (0.35 to 1.44)0.12/0.24
 Multivariate§1.00.59 (0.32 to 1.10)0.73 (0.21 to 2.61)0.14/0.33
Non-RA cohort
Total
 Univariate1.00.70 (0.54 to 0.91)0.41 (0.21 to 0.79)0.0004/<0.02
 Multivariate1.00.72 (0.56 to 0.95)0.42 (0.22 to 0.82)0.001/0.02
F13A 34VV
 Univariate1.00.39 (0.27 to 0.58)0.25 (0.10 to 0.62)<10−7/<0.0004
 Multivariate**1.00.40 (0.28 to 0.59)0.26 (0.10 to 0.64)<10−6/<0.0005
F13A 34L
 Univariate1.01.41 (0.95 to 2.09)0.82 (0.32 to 2.13)0.35/0.51
 Multivariate**1.01.47 (0.99 to 2.18)0.74 (0.28 to 1.94)0.38/0.50

  • Analyses based on the RA cohort (288 RA patients, 913 observations) and the non-RA cohort (636 non-RA patients, 2541 observations), respectively. Univariate and multivariate analyses (RA adjusted for disease duration, sex, erosive disease, shared epitope, therapy intensity; non-RA adjusted for sex, age, pregnancy, ethnicity) as well as trend tests across FGB −455A copy numbers are given.

  • ↵* padj, p value after adjustment for non-independent observations within clusters.

  • ↵† Ellipse indicates no CRP ≥10 mg/l in the FGB −455AA genotype.

  • ↵‡ p for homogeneity (RA, F13A 34VV vs F13A 34L)=0.12 (univariate).

  • ↵§ p for homogeneity (RA, F13A 34VV vs F13A 34L)=0.07 (multivariate).

  • ↵ p for homogeneity (non-RA, F13A 34VV vs F13A 34L)<10−5 (univariate).

  • ↵** p for homogeneity (non-RA, F13A 34VV vs F13A 34L)<10−4 (multivariate).

  • CRP, C-reactive protein; F13A, factor XIIIA; FGB, β-fibrinogen; RA, rheumatoid arthritis.