Table 2

Association study of ALK1 rs2277382 and ENG rs35400405 SNP in the French discovery cohort

NMAF (%)Fischer's p valuep-adj*OR (95% CI)
ALK1 rs2277382SSc8249.040.0030.0661.43 (1.13 to 1.81)
PAH–SSc5412.90.00030.00662.13 (1.24 to 3.65)
ENG rs35400405SSc8222.490.26NS1.30 (0.82 to 2.05)
PAH–SSc543.640.22NS1.92 (0.67 to 5.49)
  • ENG, endoglin gene; MAF, minor allele frequency; NA, not applicable; p-adj*, adjusted p value after Bonferroni correction for multiple SNP testing (n=22); PAH, pulmonary arterial hypertension; SNP, single-nucleotide polymorphism; SSc, systemic sclerosis.