Overall risk of CVD and sensitivity analysis for the nine studies assessing combined CVDs in patients with rheumatoid arthritis
| Study subset* | Studies (n) | Patients (n) | Cardiovascular events (n) | Random effects (pooled RR (95% CI)) | p Value |
|---|---|---|---|---|---|
| All studies | 9 | 39 901 | 2047 | 1.48 (1.36 to 1.62) | |
| Study population | |||||
| Community-based | 6 | 38 799 | 1545 | 1.53 (1.44 to 1.62) | NS |
| Clinic-based | 3 | 1102 | 502 | 1.79 (0.96 to 3.32) | |
| Cohort type | |||||
| Inception cohorts | 2 | 965 | 247 | 1.12 (0.97 to 1.30) | 0.009 |
| Non-inception cohorts | 7 | 38 936 | 1800 | 1.56 (1.47 to 1.66) | |
| Quality score | |||||
| Higher quality (score ≥10) | 5 | 1346 | 224 | 1.21 (1.06 to 1.39) | NS |
| Lower quality (score <10) | 4 | 38 555 | 1823 | 1.47 (1.35 to 1.61) | |
↵* Difference in the pooled RR between subgroups using univariate meta-regression analysis.
CVD, cardiovascular disease; NS, not significant.