Table 3

Synthesis of results for studies that estimate the correlation between changes in radiographic progression and mean HAQ score during the follow-up or HAQ score at the end of follow-up (type C comparison)

CitationVariables correlatedType of statistical analysisNo of patients for correlation (% baseline)Correlation scorep ValueAdjustments for confounders
Univariate analysis
van Leeuwen 199451Modified SharpSpearman's correlation149 (92.0%)0.306 (3 years)<0.01*no
Wolfe 199856SharpSpearman's correlation256 (100%)Sharp-HAQ: 0.212 (2 years)>0.05no
Erosion scoreErosion score-HAQ: 0.192 (2 years)>0.05
JSN – HAQJSN-HAQ: 0.212 (2 years)>−0.05
Grip strengthSharp-grip strength: 0.412 (2 years)<−0.05*
Deodhar 200364§LarsenPearson's correlation29 (72.5%)0.51 (5 years)<-0.01*No
Maillefert 200467Sharp/vdHSpearman's correlation135 (70.7%)Sharp: 0.18-0.30 (5 years)<0.05*No
JSNJSN: 0.25-0.29 (5 years)<0.05*
Erosion scoreErosion score: 0.008-0.21 (5 years)<0.05*
Multivariate analysis
Corbett 199347Erosive change – Steinbrocker gradingDiscriminant analysis64 (62.7%)Not relevant<0.05*Yes
Odegard 200670Sharp/vdHMarginal model by GEE149 (62.6%)Not relevant0.019*Yes
  • In the column named ‘variables correlated’ the measure of damage is always reported while the measure of disability is reported only when different from HAQ (in italics). In the column named ‘correlation score’ the year in brackets represents the end of follow-up.

  • * Statistically significant correlation at a p<0.05.

  • In this study data were presented for all patients for which data were available at 2-year follow-up but it was not stated how many patients were lost to follow-up at the end of the study.

  • <1 year disease duration;

  • § 1–3 years disease duration;

  • see table 2 for details on disease duration.

  • GEE, generalised estimating equations; HAQ, health assessment questionnaire; JSN, joint space narrowing; vdH, van der Heide.