Table 4

Baseline predictors of serum creatinine (log) and proteinuria (square root) at last follow-up

	Univariate analysis		Multivariate analysis
	B (95% CI)	p Value	B (95% CI)	p Value
Serum creatinine at last follow-up
Treatment (if AZA/MP)	0.034 (−0.069 to 0.137)	0.509		^†
Gender (if male)	0.279 (0.146 to 0.412)	0.000	0.230 (0.121 to 0.339)	0.000
Caucasian (if no)	0.141 (0.027 to 0.255)	0.016	0.142 (0.053 to 0.231)	0.002
Age (years)^‡	0.008 (0.004 to 0.012)	0.000	0.007 (0.004 to 0.011)	0.000
Duration of SLE (years)^‡	0.005 (−0.003 to 0.013)	0.251		^†
LN presenting symptom (if yes)	−0.043 (−0.146 to 0.059)	0.403		^†
Hypertension (if present)	0.060 (−0.072 to 0.193)	0.369		^†
C3 (% of lowest normal)^§	0.000 (−0.002 to 0.002)	0.912		^†
C4 (% of lowest normal)^§	−0.001 (−0.002 to 0.001)	0.298		^†
Anti-dsDNA (if positive)	0.059 (−0.107 to 0.225)	0.482		^†
Serum creatinine^§	0.002 (0.001 to 0.002)	0.000	0.001 (0.000 to 0.002)	0.001
Proteinuria^§	−0.013 (−0.031 to 0.005)	0.165		^*
CI^§	0.053 (0.014 to 0.092)	0.009		^*
AI^§	−0.007 (−0.021 to 0.007)	0.307		^†
Proteinuria at last follow-up
Treatment (if AZA/MP)	−0.012 (−0.232 to 0.207)	0.912		^†
Gender (if male)	0.133 (−0.177 to 0.443)	0.397		^†
Caucasian (if no)	0.350 (0.110 to 0.590)	0.005	0.359 (0.139 to 0.580)	0.002
Age (yrs)^†	−0.005 (−0.014 to 0.005)	0.332		^†
Duration of SLE (years)^‡	0.003 (−0.015 to 0.021)	0.768		^†
LN presenting symptom (if yes)	−0.107 (−0.325 to 0.112)	0.333		^†
Hypertension (if present)	0.042 (−0.242 to 0.325)	0.771		^†
C3 (% of lowest normal)^§	0.002 (−0.002 to 0.006)	0.362		^†
C4 (% of lowest normal)^§	0.001 (−0.001 to 0.002)	0.299		^†
Anti-dsDNA (if positive)	0.118 (−0.238 to 0.474)	0.512		^†
Serum creatinine^§	0.001 (0.000 to 0.003)	0.131		^*
Proteinuria^§	−0.004 (−0.043 to 0.034)	0.823		^†
CI^§	0.141 (0.059 to 0.222)	0.001	0.118 (0.040 to 0.195)	0.003
AI^§	−0.035 (−0.063 to −0.007)	0.016	−0.030 (−0.056 to −0.004)	0.026

B refers to the influence on serum creatinine and proteinuria at last follow-up.
↵* The variable was not selected during multivariate linear regression analysis.
↵† The variable was not tested in multivariate linear regression analysis because of a p value >0.2 in univariate linear regression analysis.
↵‡ per year.
↵§ per 1 grade or 1 point.
AI, activity index; Anti-dsDNA, antidouble-stranded DNA antibodies; AZA/MP, azathioprine/methylprednisolone; C3, complement factor 3; C4, complement factor 4; CI, chronicity index; LN, lupus nephritis; SLE, systemic lupus erythematosus; B, regression coefficient.