Baseline predictors of serum creatinine (log) and proteinuria (square root) at last follow-up
Univariate analysis | Multivariate analysis | |||
---|---|---|---|---|
B (95% CI) | p Value | B (95% CI) | p Value | |
Serum creatinine at last follow-up | ||||
Treatment (if AZA/MP) | 0.034 (−0.069 to 0.137) | 0.509 | † | |
Gender (if male) | 0.279 (0.146 to 0.412) | 0.000 | 0.230 (0.121 to 0.339) | 0.000 |
Caucasian (if no) | 0.141 (0.027 to 0.255) | 0.016 | 0.142 (0.053 to 0.231) | 0.002 |
Age (years)‡ | 0.008 (0.004 to 0.012) | 0.000 | 0.007 (0.004 to 0.011) | 0.000 |
Duration of SLE (years)‡ | 0.005 (−0.003 to 0.013) | 0.251 | † | |
LN presenting symptom (if yes) | −0.043 (−0.146 to 0.059) | 0.403 | † | |
Hypertension (if present) | 0.060 (−0.072 to 0.193) | 0.369 | † | |
C3 (% of lowest normal)§ | 0.000 (−0.002 to 0.002) | 0.912 | † | |
C4 (% of lowest normal)§ | −0.001 (−0.002 to 0.001) | 0.298 | † | |
Anti-dsDNA (if positive) | 0.059 (−0.107 to 0.225) | 0.482 | † | |
Serum creatinine§ | 0.002 (0.001 to 0.002) | 0.000 | 0.001 (0.000 to 0.002) | 0.001 |
Proteinuria§ | −0.013 (−0.031 to 0.005) | 0.165 | * | |
CI§ | 0.053 (0.014 to 0.092) | 0.009 | * | |
AI§ | −0.007 (−0.021 to 0.007) | 0.307 | † | |
Proteinuria at last follow-up | ||||
Treatment (if AZA/MP) | −0.012 (−0.232 to 0.207) | 0.912 | † | |
Gender (if male) | 0.133 (−0.177 to 0.443) | 0.397 | † | |
Caucasian (if no) | 0.350 (0.110 to 0.590) | 0.005 | 0.359 (0.139 to 0.580) | 0.002 |
Age (yrs)† | −0.005 (−0.014 to 0.005) | 0.332 | † | |
Duration of SLE (years)‡ | 0.003 (−0.015 to 0.021) | 0.768 | † | |
LN presenting symptom (if yes) | −0.107 (−0.325 to 0.112) | 0.333 | † | |
Hypertension (if present) | 0.042 (−0.242 to 0.325) | 0.771 | † | |
C3 (% of lowest normal)§ | 0.002 (−0.002 to 0.006) | 0.362 | † | |
C4 (% of lowest normal)§ | 0.001 (−0.001 to 0.002) | 0.299 | † | |
Anti-dsDNA (if positive) | 0.118 (−0.238 to 0.474) | 0.512 | † | |
Serum creatinine§ | 0.001 (0.000 to 0.003) | 0.131 | * | |
Proteinuria§ | −0.004 (−0.043 to 0.034) | 0.823 | † | |
CI§ | 0.141 (0.059 to 0.222) | 0.001 | 0.118 (0.040 to 0.195) | 0.003 |
AI§ | −0.035 (−0.063 to −0.007) | 0.016 | −0.030 (−0.056 to −0.004) | 0.026 |
B refers to the influence on serum creatinine and proteinuria at last follow-up.
↵* The variable was not selected during multivariate linear regression analysis.
↵† The variable was not tested in multivariate linear regression analysis because of a p value >0.2 in univariate linear regression analysis.
↵‡ per year.
↵§ per 1 grade or 1 point.
AI, activity index; Anti-dsDNA, antidouble-stranded DNA antibodies; AZA/MP, azathioprine/methylprednisolone; C3, complement factor 3; C4, complement factor 4; CI, chronicity index; LN, lupus nephritis; SLE, systemic lupus erythematosus; B, regression coefficient.