Disease activity for each ESSDAI domain
| Domain | Outcome | Baseline | Week 16 | Week 24 | Week 36 | Week 48 | Week 60 |
|---|---|---|---|---|---|---|---|
| Constitutional | No/low/moderate, n | 16/12/0 | 26/2/0 | 25/3/0 | 27/1/0 | 23/5/0 | 23/3/1 |
| No/low/moderate, % | 57/43/0 | 93/7/0 | 89/11/0 | 96/4/0 | 82/18/0 | 85/11/4 | |
| Lymphadenopathy | No/low/moderate/high, n | 28/0/0/0 | 28/0/0/0 | 28/0/0/0 | 28/0/0/0 | 28/0/0/0 | 26/1/0/0 |
| No/low/moderate/high, % | 100/0/0/0 | 100/0/0/0 | 100/0/0/0 | 100/0/0/0 | 100/0/0/0 | 96/4/0/0 | |
| Glandular | No/low/moderate, n | 11/15/2 | 27/1/0 | 25/3/0 | 24/4/0 | 23/5/0 | 17/10/0 |
| No/low/moderate, % | 39/54/7 | 96/4/0 | 89/11/0 | 86/14/0 | 82/18/0 | 63/37/0 | |
| Articular | No/low/moderate/high, n | 20/3/4/1 | 27/0/1/0 | 26/2/0/0 | 23/4/0/1 | 21/3/3/1 | 18/4/3/2 |
| No/low/moderate/high, % | 71/11/14/4 | 96/0/4/0 | 93/7/0/0 | 82/14/0/4 | 75/11/11/4 | 67/15/11/7 | |
| Cutaneous | No/low/moderate/high, n | 24/0/3/1 | 25/0/3/0 | 28/0/0/0 | 26/2/0/0 | 25/0/2/1 | 21/1/3/2 |
| No/low/moderate/high, % | 86/0/11/4 | 89/0/11/0 | 100/0/0/0 | 93/7/0/0 | 89/0/7/4 | 78/4/11/7 | |
| Pulmonary | No/low/moderate/high, n | 25/3/0/0 | 26/2/0/0 | 24/4/0/0 | 27/0/1/0 | 26/2/0/0 | 22/5/0/0 |
| No/low/moderate/high, % | 89/11/0/0 | 93/7/0/0 | 86/14/0/0 | 96/0/4/0 | 93/7/0/0 | 82/19/0/0 | |
| Renal | No/low/moderate/high, n | 27/1/0/0 | 27/1/0/0 | 27/1/0/0 | 27/1/0/0 | 27/0/1/0 | 26/1/0/0 |
| No/low/moderate/high, % | 96/4/0/0 | 96/4/0/0 | 96/4/0/0 | 96/4/0/0 | 96/0/4/0 | 96/4/0/0 | |
| Muscular | No/low/moderate/high, n | 28/0/0/0 | 28/0/0/0 | 28/0/0/0 | 28/0/0/0 | 27/0/0/1 | 26/1/0/0 |
| No/low/moderate/high, % | 100/0/0/0 | 100/0/0/0 | 100/0/0/0 | 100/0/0/0 | 96/0/0/4 | 96/4/0/0 | |
| PNS | No/low/moderate/high, n | 26/2/0/0 | 28/0/0/0 | 28/0/0/0 | 28/0/0/0 | 28/0/0/0 | 25/1/1/0 |
| No/low/moderate/high, % | 93/7/0/0 | 100/0/0/0 | 100/0/0/0 | 100/0/0/0 | 100/0/0/0 | 93/4/4/0 | |
| CNS | No/low/high, n | 28/0/0 | 28/0/0 | 28/0/0 | 28/0/0 | 28/0/0 | 27/0/0 |
| No/low/high, % | 100/0/0 | 100/0/0 | 100/0/0 | 100/0/0 | 100/0/0 | 100/0/0 | |
| Haematological | No/low/moderate/high, n | 17/10/0/1 | 23/5/0/0 | 22/5/1/0 | 23/5/0/0 | 21/6/1/0 | 21/4/2/0 |
| No/low/moderate/high, % | 61/36/0/4 | 82/18/0/0 | 79/18/4/0 | 82/18/0/0 | 75/21/4/0 | 78/15/7/0 | |
| Biological | No/low/moderate, n | 4/10/14 | 11/8/9 | 12/7/9 | 11/9/8 | 12/9/7 | 12/6/9 |
| No/low/moderate, % | 14/36/50 | 39/29/32 | 43/25/32 | 39/32/29 | 42/32/25 | 44/22/33 |
CNS, central nervous system; ESSDAI, EULAR Sjögren's Syndrome Disease Activity Index; PNS, peripheral nervous system.