Percentage with protective antibody concentrations | |||||||
---|---|---|---|---|---|---|---|
Seroprotection | N | JIA | HC | Unadjusted OR (95% CI) | p Value | Adjusted OR* (95% CI) | p Value |
Cohort ≥1986 | |||||||
Measles | 1780 | 93.9 | 87.4 | 2.2 (1.4 to 3.5) | 0.001 | 1.4 (0.8 to 2.5) | 0.233 |
Mumps | 1783 | 85.1 | 85.0 | 1.0 (0.7 to 1.4) | 0.953 | 0.4 (0.3 to 0.6) | <0.001 |
Rubella | 1782 | 89.8 | 90.3 | 0.9 (0.6 to 1.4) | 0.789 | 0.4 (0.3 to 0.7) | 0.001 |
Diphtheria | 1621 | 90.5 | 98.5 | 0.1 (0.08 to 0.3) | <0.001 | 0.1 (0.06 to 0.2) | <0.001 |
Tetanus | 1621 | 95.7 | 99.1 | 0.2 (0.1 to 0.5) | <0.001 | 0.1 (0.05 to 0.3) | <0.001 |
Cohort 1976–85 | |||||||
Measles | 791 | 94.6 | 91.0 | 1.7 (0.4 to 7.4) | 0.455 | 2.1 (0.5 to 9.2) | 0.319 |
Mumps | 790 | 81.1 | 94.8 | 0.2 (0.1 to 0.6) | 0.001 | 0.1 (0.05 to 0.4) | <0.001 |
Rubella | 791 | 81.1 | 98.8 | 0.05 (0.02 to 0.1) | <0.001 | 0.03 (0.01 to 0.1) | <0.001 |
Diphtheria | 783 | 77.1 | 98.9 | 0.04 (0.01 to 0.1) | <0.001 | 0.04 (0.01 to 0.1) | <0.001 |
Tetanus | 783 | 94.3 | 99.3 | 0.1 (0.02 to 0.6) | 0.010 | 0.1 (0.02 to 0.6) | 0.010 |
↵* The OR indicates the odds of having protective antibody levels for JIA patients compared with healthy controls. In logistic regression analysis the OR were adjusted for age and the number of vaccinations at the time of sampling.
HC, healthy controls; JIA, juvenile idiopathic arthritis.