Before RTX | After RTX | p Value | |
---|---|---|---|
Disease activity, BVAS, median (range) | 11 (1–28) | 5 (0–20) | <0.05 |
Disease Extent Index, median (range) | 4 (2–8) | 2 (0–6) | <0.05 |
Laboratory parameters | |||
ESR, mm after 1 h | 40 (6–150) | 40 (2–94) | <0.05 |
CRP, mg/dl | 1.5 (0–277) | 1.1 (0–50.6) | <0.05 |
ANCA titre (l) | 128 (0–4096) | 32 (0–2048) | 0.01 |
Prednisolone dose (mg/day), median (range) | 15 (0–90) | 8 (0–80) | 0.01 |
Immunoglobulin levels* | |||
IgM (g/l), median (range) | 0.51 (0.1–1.8) | 0.2 (0.1–1.4) | <0.05 |
IgG (g/l), median (range) | 8.6 (4.5–13.6) | 6.9 (2.1–13.1) | <0.05 |
↵* Available for 39 cases. (For decline in ANCA titre see online supplementary files.)
ANCA, antineutrophil cytoplasmic antibody; BVAS, Birmingham Vasculitis Activity Score; CRP, C-reactive protein; DEI, Disease Extent Index; ESR, erythrocyte sedimentation rate; RTX, rituximab.