Predictive value of baseline to 2-year change in laboratory and renal biopsy parameters
| Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
| HR/B (95% CI) | p Value | HR/B (95% CI) | p Value | |
| Time to occurrence of renal relapse (after 2 years) | ||||
| Δ C3 (% of lowest normal) | 1.019 (1.004 to 1.035) | 0.013 | * | |
| Δ C4 (% of lowest normal) | 1.002 (0.997 to 1.007) | 0.412 | † | |
| Δ anti-dsDNA | 0.993 (0.985 to 1.001) | 0.075 | * | |
| Δ serum creatinine | 0.981 (0.964 to 1.000) | 0.047 | * | |
| Δ proteinuria | 1.005 (0.821 to 1.232) | 0.959 | † | |
| Δ CI (n=39) | 1.027 (0.727 to 1.451) | 0.881 | † | |
| Δ AI (n=39) | 0.845 (0.711 to 1.005) | 0.056 | 0.733 (0.545 to 0.985) | 0.039 |
| Serum creatinine at last follow-up | ||||
| Δ C3 (% of lowest normal) | 0.001 (0.000 to 0.002) | 0.030 | * | |
| Δ C4 (% of lowest normal) | −0.000 (−0.001 to 0.000) | 0.865 | † | |
| Δ anti-dsDNA | −0.000 (−0.000 to 0.000) | 0.070 | * | |
| Δ serum creatinine | 0.000 (−0.001 to 0.000) | 0.397 | † | |
| Δ proteinuria | −0.019 (−0.035 to −0.003) | 0.020 | −0.024 (−0.043 to −0.004) | 0.017 |
| Δ CI (n=39) | −0.001 (−0.034 to 0.033) | 0.962 | † | |
| Δ AI (n=39) | −0.007 (−0.021 to 0.008) | 0.363 | † | |
| Proteinuria at last follow-up | ||||
| Δ C3 (% of lowest normal) | 0.000 (−0.002 to 0.002) | 0.773 | † | |
| Δ C4 (% of lowest normal) | 0.000 (−0.001 to 0.001) | 0.893 | † | |
| Δ anti-dsDNA | 0.000 (−0.000 to 0.000) | 0.189 | * | |
| Δ serum creatinine | 0.000 (−0.002 to 0.002) | 0.917 | † | |
| Δ proteinuria | −0.002 (−0.030 to 0.027) | 0.911 | † | |
| Δ CI (n=39) | 0.088 (−0.011 to 0.187) | 0.081 | * | |
| Δ AI (n=39) | −0.043 (−0.086 to 0.000) | 0.051 | * | |
HR (hazard ratio) refers to the risk of occurrence of renal relapse: per 1 grade or 1 point.
B (regression coefficient) refers to the influence on serum creatinine and proteinuria at last follow-up: per 1 grade or 1 point.
Δ baseline to 2-year change.
↵* The variable was not selected during multivariate Cox or linear regression analysis.
↵† The variable was not tested in multivariate Cox or linear regression analysis because of a p value >0.2 in univariate Cox or linear regression analysis.
AI, activity index; anti-dsDNA, anti-double-stranded DNA antibodies; C3, complement factor 3; C4, complement factor 4; CI, chronicity index.