Pubertal characteristics of the 147/276 (53.3%) evaluable females with juvenile SLE
| Patients included for pubertal evaluation*(N=147) | |
|---|---|
| Patients who had menarche registered, n | 104/147 (70.7%) |
| Age at menarche, median (1st, 3rd quartile) | 13.6 (12.6, 14.5) |
| Tanner ≥B2 at last visit | 141/147 (95.9%) |
| Age at B2, median (1st, 3rd quartile) | 11.9 (11.1, 12.7) |
| Delayed pubertal onset† | 11/72 (15.3%) |
| Delayed pubertal tempo‡ | 37/96 (38.5%) |
| Delayed or absent menarche | 25/114 (21.9%) |
| Delayed menarche§ | 15/114 (13.1%) |
| Absent menarche¶ | 10/114 (8.8%) |
| Normal menarche | 89/114 (78.1%) |
| Delayed puberty** | 53/147 (36.1%) |
| Irregular menses or postmenarche amenorrhoea | 48/104 (46.2%) |
Numbers are medians (1st, 3rd quartiles) or frequencies (%).
↵* A total of 147 female patients were included in pubertal evaluation, and 129 were excluded as 114 patients had already completed puberty before disease onset and 15 patients had no menarche but were <13 years of age at last follow-up (too young to be informative).
↵† Age at B2 ≥13 years.
↵‡ Delayed pubertal tempo (stable Tanner stage for ≥1 year in late-maturing girl or ≥2 years in normal-maturing girl).
↵§ Age at menarche ≥15 years.
↵¶ No menarche and age at last follow-up ≥15 years.
↵** Delayed puberty was defined as either delayed pubertal onset, delayed pubertal tempo (stable Tanner stage for ≥1 year in late-maturing girl or ≥2 years in normal-maturing girl), or delayed or absent menarche.