Table 4

Growth and pubertal outcome in juvenile systemic lupus erythematosus after 26 months according to age at disease onset

FemalesMales
Onset age <12 yOnset age ≥12 yOnset age <14 yOnset age ≥14 y
n*n (%)n*n (%)pn*n (%)n*n (%)p
Growth failure10528 (22.4)1205 (3.3)<0.00013611 (30.6)131 (7.7)0.06
Height deflection§12546 (36.8)15111 (7.3)<0.00014222 (52.4)133 (23.1)0.10
Delayed puberty9535 (36.8)5218 (34.6)0.7925114400 (0)
Delayed or absent menarche**6514 (21.5)4911 (22.4)0.91
  • * Number of patients that could be evaluated for the given characteristic.

  • χ2 test.

  • Defined as parent-adjusted height z score <−1.5.

  • § Defined as Δheight z score <−0.25/year from baseline to the following assessments.

  • Either delayed pubertal onset (age at B2 ≥13 years in females or age at T2 ≥14 years in males), delayed pubertal tempo (stable Tanner stage for ≥1 year in late-maturing child or ≥2 years in normal-maturing child) and/or (for females) delayed menarche.

  • ** Age at menarche ≥15 years or no menarche and age at last visit ≥15 years.