APS and its association with immune diseases
| Variable | SN-APS (n=67) | SP-APS (n=87) | p value |
|---|---|---|---|
| Immune diseases | |||
| CTD | 16 (23.8%) | 38 (43.6%) | 0.01 |
| SLE | 11 (16.4%) | 34 (39.0%) | <0.001 |
| Sjögren's syndrome | 2 (2.9%) | 12 (13.8%) | 0.02 |
| Non-CTD immune disease | 12 (17.9%) | 26 (29.8%) | 0.09 |
| Thyroiditis | 7 (10.4%) | 18 (20.6%) | 0.12 |
| Haemolytic anaemia | 0 | 3 (3.4%) | 0.25 |
| Immunological profile | |||
| ANA | 15 (22.3%) | 47 (54.0%) | <0.001 |
| DNA(ds) | 0 | 12 (13.7%) | <0.001 |
| ENA | 6 (8.9%) | 14 (16.0%) | 0.23 |
| Sm | 1 (1.5%) | 1 (1.1%) | 0.85 |
| Ro | 3 (4.4%) | 11 (12.6%) | 0.09 |
| La | 1 (1.5%) | 4 (4.5%) | 0.38 |
| RNP | 3 (4.4%) | 2 (2.9%) | 0.65 |
| Rheumatoid factor | 19 (28.3%) | 19 (21.8%) | 0.45 |
ANA, Antinuclear antibody; APS, antiphospholipid syndrome; CTD, connective tissue disease; ENA, extractable nuclear antigen; RNP, ribonucleoprotein; Sm, smith; SLE, systemic lupus erythematosus; SN-APS, the so-called seronegative APS; SP-APS, seropositive APS.