Change in outcomes from baseline after 52 weeks in knee osteoarthritis patients who were randomised to either an intensive low-energy diet (LED) or a control group
| Treatment | Comparison | |||
|---|---|---|---|---|
| Variable | LED (NLED=44) | Control (NControl=45) | Difference in means (95% CI) | p Value |
| Primary outcome | ||||
| ΔWOMAC index (0–100 mm) | −7.3±1.9 | −3.0±1.9 | 4.3 (−0.9 to 9.6) | 0.1074 |
| Secondary outcomes | ||||
| WOMAC: >50% improvement (n (%)) | 14 (31.8) | 7 (15.6) | 16.3% (−1.1% to 33.6%) | 0.0664 |
| ΔWOMAC pain (0–100 mm) | −7.7±2.2 | −0.5±2.2 | 7.2 (1.0 to 13.4) | 0.0220 |
| ΔWOMAC disability (0–100 mm) | −7.5±2.0 | −3.9±2.0 | 3.7 (−1.9 to 9.2) | 0.1938 |
| ΔWOMAC stiffness (0–100 mm) | −6.2±2.7 | −3.9±2.7 | 2.3 (−5.3 to 9.9) | 0.5526 |
| ΔHAQ (score 0–3) | −0.12±0.03 | −0.04±0.03 | 0.08 (−0.00 to 0.17) | 0.0611 |
| ΔWeight (kg) | −10.9±0.8 | −3.6±0.8 | 7.3 (5.0 to 10.0) | <0.0001 |
| ΔWeight (%) | −11.3±0.8 | −3.7±0.8 | 7.5 (5.2 to 9.9) | <0.0001 |
| ΔFat mass (kg) | −8.5±0.7 | −2.9±0.7 | 5.5 (3.7 to 7.4) | <0.0001 |
| ΔFat percentage (%point) | −3.7±0.4 | −1.3±0.4 | 2.5 (1.3 to 3.7) | <0.0001 |
| Losing >10% body weight (n (%)) | 24 (54.5) | 4 (8.9) | 45.7% (28.8% to 62.6%) | <0.0001 |
Values are mean±SE unless otherwise stated.
HAQ, Health Assessment Questionnaire; WOMAC, Western Ontario and McMaster Universities Osteoarthritis index.