Association of baseline IL-22 serum levels with erosive disease
| ‘IL-22 normal’ (n=25)* | ‘IL-22 high’ (n=24)† | p Value‡ | |
|---|---|---|---|
| Erosive disease at baseline | 1/25 (4) | 8/24 (33) | 0.05 |
| Erosive disease after 1 year | 1/24§ (4) | 13/23§ (57) | <0.01 |
| Erosive disease after 2 years | 1/24§ (4) | 14/23§ (61) | <0.005 |
Results are shown as number (%).
↵* Patients with RA characterised by a normal IL-22 serum level (<7.5 pg/ml).
↵† Patients with RA characterised by a raised IL-22 serum level (>7.5 pg/ml).
↵‡ Multivariate regression analysis was performed to control for confounding effects of anti-CCP-and RF positivity, baseline CRP and DAS28.
↵§ One patient from each group was lost during follow-up.
anti-CCP, anti-cyclic citrullinated peptides; CRP, C-reactive protein; DAS28, Disease Activity Score in 28 joints; IL-22, interleukin 22; RA, rheumatoid arthritis; RF, rheumatoid factor.