Progression from baseline to 9-year follow-up (%) in individuals with radiographic HOA at baseline
| Men (n=187) | Women (n=277) | |
|---|---|---|
| Progression of HOA (change in summed KL score ≥1) | 91.4 (87.4 to 95.5) | 96.4 (94.2 to 98.6) |
| DIP (2nd–5th) OA | 59.4 (52.3 to 66.4) | 78.3 (73.4 to 83.1)* |
| PIP (2nd–5th) OA | 41.2 (34.1 to 48.2) | 57.0 (51.2 to 62.9) |
| Thumb IP OA | 31.6 (24.9 to 38.2) | 39.7 (33.9 to 45.5) |
| MCP (1st–5th) OA | 39.0 (32.0 to 46.0) | 24.5 (19.5 to 29.6) |
| Thumb base OA | 64.8 (57.9 to 71.8)* | 70.7 (65.2 to 76.1)* |
| Wrist OA | 3.2 (0.7 to 5.7) | 1.4 (0.0 to 2.8) |
| Change in total KL score (all hand joints) | 7.8 (6, 2–12) | 10.2 (9, 4–15) |
| Change in number of HOA joints (KLG≥2) | 5.0 (4, 2–8) | 6.4 (6, 3–9) |
| Number of joints with incident disease | 2.8 (2, 1–4) | 3.6 (3, 1–5) |
| Number or HOA joints with progression | 1.4 (1, 0–2) | 1.8 (1, 0–2) |
| Development of erosive HOA (≥1 joint(s))† | 9.6 (5.2 to 13.9) | 17.3 (12.4 to 22.2) |
| Development of symptomatic HOA (≥1 joint(s))‡ | 25.9 (19.1 to 32.8) | 33.7 (26.8 to 40.6) |
Data presented as % (95% CI), except for changes in total KL score and number of affected joints presented as mean (median, interquartile range).
↵* One woman with max KL score for the DIP joints, 4 men and 10 women with max KL scores for the thumb base joints were excluded from analyses.
↵† In subjects with non-erosive HOA at baseline (178 men, 231 women).
↵‡ In subjects with non-symptomatic HOA at baseline (158 men, 181 women).
DIP, distal interphalangeal; HOA, hand osteoarthritis; IP, interphalangeal; KL, Kellgren and Lawrence; KLG, Kellgren–Lawrence grade; MCP, metacarpophalangeal; OA, osteoarthritis; PIP, proximal interphalangeal.