Table 1

Descriptive characteristics of study subjects

Cohort name
Genetics of Osteoarthritis and LifestyleHertfordshire Cohort StudyNottingham Case-Control StudyChingford StudyTwinsUK StudyClearwater Osteoarthritis StudyTasmanian Older Adult Cohort
Cohort acronymGOALHCSNottChingfordTwinsUKCOSTASOAC
Country of originUKUKUKUKUKUSAAustralia
Knee OA
Symptomaticn=1199n=86n=1703n=68n=45n=83n=86
Age (years), mean (SD)68.4 (7.2)65.3 (2.8)68.7 (8.9)65.7 (5.8)57.5 (7.2)65.6 (8.3)65.0 (7.2)
Female (%)46.944.355.310010066.758.50
BMI (kg/m2), mean (SD)31.2 (5.4)29.7 (5.4)29.7 (5.4)26.7 (3.4)27.9(4.5)29.1 (5.1)31.3 (6.3)
K/L≥3 (%)89.738.680.844.129.032.942.6
TKR (%)94.89.390.323.526.7240
TRPV1 585 Ile–Ile (%)11.412.812.98.89.315.512.6
MAF (%)35.137.236.938.231.433.835.1
Asymptomaticn=376n=44n=0n=216n=235n=91n=136
Age (years), mean (SD)69.0 (6.7)65.2 (6.4)N/A65.7 (5.9)58.1 (7.8)64.0 (9.8)65.8 (7.6)
Female (%)43.931.8N/A10010054.643.80
BMI (kg/m2), mean (SD)28.9 (4.9)28.4 (4.0)N/A26.2 (4.4)26.7 (4.9)26.1 (4.7)28.1 (4.3)
K/L≥3 (%)49.515.9N/A26.434.021.724.8
TKR (%)00N/A0000
TRPV1 585 Ile–Ile (%)14.411.9N/A11.717.117.618.4
MAF (%)38.240.4N/A37.440.243.543.4
Unaffectedn=743n=542n=728n=532n=978n=0n=329
Age years mean (SD)62.6 (8.4)64.8 (2.7)66.3 (7.4)62.9 (5.7)52.9 (7.2)N/A61.8 (7.5)
Female (%)49.950.157.4100100N/A47.9
BMI (kg/m2) mean (SD)27.1 (4.4)26.2 (3.8)26.6(3.9)24.7 (3.6)24.5 (4.0)N/A27.4 (4.4)
TRPV1 585 Ile–Ile (%)15.515.616.113.615.0N/A16.20
MAF (%)38.538.537.838.137.838.8
  • BMI, body mass index; K/L, Kellgren–Lawrence; MAF, minor allele frequency; TKR, total knee replacement.