Summary statistics for primary case–control analysis of seven previously identified psoriasis SNPs
| SNP | Cases | Controls | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| rs | Locus | Gene* | Alleles | MAF | HWE | 11 | 12 | 22 | MAF | HWE | 11 | 12 | 22 | Trend p value | OR (CI) |
| rs2066808 | 12q13 | IL23A | G/A | 0.04 | 0.65 | 2 (0.2) | 68 (7.5) | 832 (92.2) | 0.07 | 0.84 | 26 (0.5) | 733 (13.3) | 4770 (86.3) | 9.05×10−7 | 0.54 (0.43 to 0.70) |
| rs17728338 | 5q33 | TNIP1 | A/G | 0.08 | 1.00 | 5 (0.6) | 133 (14.7) | 765 (84.7) | 0.05 | 0.80 | 15 (0.3) | 575 (10.4) | 4942 (89.3) | 3.53×10−5 | 1.49 (1.23 to 1.80) |
| rs495337 | 20q13 | RNF114 | T/C | 0.38 | 0.38 | 136 (13.9) | 477 (48.7) | 367 (37.4) | 0.42 | 0.64 | 427 (18.1) | 1142 (48.3) | 795 (33.6) | 2.5×10−3 | 0.85 (0.76 to 0.94 |
| rs610604 | 6q23 | TNFAIP3 | G/T | 0.34 | 0.02 | 91 (10.1) | 440 (48.7) | 372 (41.2) | 0.32 | 0.04 | 593 (10.7) | 2335 (42.2) | 2604 (47.1) | 0.03 | 1.13 (1.01 to 1.25) |
| rs1076160 | 9q34 | TSC1 | T/C | 0.47 | 0.26 | 192 (21.3) | 467 (51.8) | 243 (26.9) | 0.50 | 0.45 | 1364 (24.7) | 2793 (50.5) | 1371 (24.8) | 0.03 | 0.9 (0.81 to 0.99) |
| rs12983316 | 19p13 | SMARCA4 | G/A | 0.16 | 0.9 | 22 (2.4) | 245 (27.3) | 632 (70.3) | 0.16 | 0.12 | 128 (2.3) | 1526 (27.6) | 3870 (70.1) | 0.95 | 1.00 (0.87 to 1.14) |
| rs397211 | 2q13 | IL1RN | C/T | 0.29 | 0.22 | 82 (9.2) | 352 (39.3) | 462 (51.6) | 0.31 | 0.34 | 509 (9.2) | 2388 (43.2) | 2631 (47.6) | 0.09 | 0.91 (0.81 to 1.01) |
↵* Proximal gene of interest.
HWE, Hardy–Weinberg equilibrium; MAF, minor allele frequency; SNP, single-nucleotide polymorphism.