Table 2

Baseline clinical features of all patients

VariableControlIVIg (all)SRSDp Value (control vs IVIg)
Global disease activity
 Disease activity score (mean±SD)7.28±2.617.06±2.540.35
Skin disease
 Heliotrope33/48 (69%)21/30 (70%) 8/14 (57%)13/16 (81%)1.00
 Gottron's33/48 (69%)17/30 (57%) 7/14 (50%)10/16 (63%)0.34
 Skin rash46/47 (98%)28/30 (93%)12/14 (86%)16/16 (100%)0.56
 Photosensitivity 7/47 (15%)14/30 (47%) 4/14 (29%)10/16 (63%)0.004
 Abnormal nail folds40/43 (93%)23/28 (82%)11/13 (85%)12/15 (80%)0.25
Constitutional disease
 Dysphagia 8/48 (17%)10/30 (33%) 7/14 (50%) 3/16 (19%)0.10
 Weight loss30/48 (63%)10/29 (34%) 5/13 (38%) 5/16 (31%)0.02
Musculoskeletal disease and functional status
 MMT*(48) 55±11(30) 45±16(14) 40±17(16) 49±150.002
 Arthritis36/48 (75%)22/30 (73%)14/14 (100%) 8/16 (50%)1.00
 CHAQ*(38) 1.2±0.8(18) 1.2±0.8(9) 1.2±0.9(9) 1.1±0.81.00
Muscle enzymes
 Abnormal creatine phosphate kinase20/48 (42%)21/30 (70%)11/14 (79%)10/16 (63%)0.02
 Abnormal aspartate aminotransferase37/48 (77%)28/30 (93%)14/14 (100%)14/16 (88%)0.26
 Abnormal alanine aminotransferase28/47 (60%)20/30 (67%)13/14 (93%) 7/16 (44%)0.64
  • * For MMT and CHAQ rows, ( ) indicates the number of patients with data, followed by mean±SD; other rows show number of subjects/total subjects (% of total subjects).

  • CHAQ, child health assessment questionnaire; IVIg, intravenous immunoglobulin; MMT, manual muscle testing; SD, corticosteroid dependent; SR, corticosteroid resistant.