Table 2

Correlations between ASDAS, BASDAI, swollen joint count and biomarker levels at baseline and between percentage changes in these from baseline to week 22

BaselinePercentage change from baseline to week 22
ASDASBASDAISJCCRPASDASBASDAISJCCRP
CRP0.73***0.79***0.44*
IL-60.39*0.63***0.62***0.320.77***
VEGF0.49***0.48***0.330.50***
YKL-40
CTX-II0.290.35
Aggrecan−0.37*−0.34
MMP-30.300.35*0.260.39*0.280.380.34
COMP0.42*−0.31
CTX-I
Osteocalcin−0.43*−0.46*
  • Spearman rank correlation coefficients:

  • * p<0.01;

  • ** p<0.001;

  • *** p<0.0001.

  • –, no correlation.

    The analyses included 60 patients at baseline and 53 patients at week 22. ASDAS could not be determined in four patients at baseline and improvement in ASDAS could not be established in five patients at week 22, and the analyses included 56 patients at baseline and 48 patients at week 22. Seven patients were excluded before week 22.

    ASDAS, ankylosing spondylitis disease activity score; BASDAI, Bath ankylosing spondylitis disease activity index; COMP, cartilage oligomeric matrix protein; CRP, C-reactive protein; CTX-I, C-terminal cross-linking telopeptide of type I collagen; CTX-II, C-terminal crosslinking telopeptide of type II collagen; IL-6, interleukin 6; MMP-3, matrix metalloproteinase 3; SJC, swollen joint count; VEGF, vascular endothelial growth factor.