Table 4

ATIC SNPs investigated for association with response to MTX in the US Cincinnati dataset

SNPGeneChromosomePositionMinor alleleMajor alleleMAF NRMAF 70%OR (95% CI)p Trend
rs13005416*ATIC2216196045CA0.510.391.62 (1.01 to 2.59)0.07
rs4673990ATIC2215914298CT0.450.520.76 (0.48 to 1.21)0.29
  • * r2=1 with rs12995526.

  • MAF, minor allele frequency; MTX, methotrexate; NR, non-responder; SNP, single nucleotide polymorphism.