Prevaccination | Posvaccination | |||||
---|---|---|---|---|---|---|
Subset | GMT | Seroprotection | GMT | Seroprotection | Factor increase | Seroconversion |
Controls(234) | 9.3(8.2 to 10.5) | 11.5(7.4 to 15.6) | 122.9(103.5 to 146.0) | 82.9(77.5 to 87.5) | 13.2(11.1 to 15.8) | 76.9(71.0 to 82.2) |
RA group(340) | 8.0(7.3 to 8.8) | 10.8(7.5 to 14.1) | 57.5(48.0 to 68.9)* | 60.0(54.5 to 65.3)* | 7.2(6.1 to 8.5)* | 53.2(47.8 to 58.6)* |
RF (340) | ||||||
No (91) | 7.8(6.5 to 9.4) | 9.6(3.3 to 16.0) | 48.1(33.2 to 69.6)* | 54.2(43.4 to 65.0)* | 6.2(4.4 to 8.7)* | 48.2(37.4 to 59.0)* |
Yes (249) | 7.9(7.1 to 8.8)* | 10.0(6.3 to 13.8) | 59.6(48.2 to 73.6)* | 64.5(55.4 to 67.5)* | 7.5(6.2 to 9.2)* | 54.2(48.0 to 60.4)* |
Corticosteroids | ||||||
No (93) | 7.8(7.0 to 8.6)* | 10.1(6.4 to 13.9) | 58.4(47.1 to 72.5)* | 60.3(54.2 to 66.4)* | 7.5(6.2 to 9.2)* | 54.7(48.4 to 60.9)* |
Yes (247) | 8.6(7.2 to 10.4) | 12.9(6.1 to 19.7) | 55.1(39.4 to 77.0)* | 59.1(49.0 to 69.2)* | 6.4(4.7 to 8.7)* | 49.5(39.2 to 59.7)* |
Methotrexate | ||||||
No (125) | 8.0(6.9 to 9.2) | 12.9(7.0 to 12.8) | 90.9(66.3 to 124.9) † | 71.8(63.8 to 79.7)*† | 11.4(8.4 to 15.4) † | 65.3(56.9 to 73.7) † |
Yes (215) | 8.0(7.1 to 9.0) | 9.7(5.8 to 13.7) | 44.2(35.7 to 54.7)*† | 53.2(46.6 to 59.9)*† | 5.5(4.6 to 6.7)*† | 46.3(39.6 to 53.0)*† |
Chloroquine | ||||||
No (216) | 7.6(6.8 to 8.5) | 10.1(6.1 to 14.2) | 57.4(45.4 to 72.6)* | 60.8(54.3 to 67.3)* | 7.5(6.1 to 9.3)* | 55.3(48.7 to 61.9)* |
Yes (124) | 8.7(7.5 to 10.1) | 12.2(6.4 to 18.0) | 57.7(43.5 to 76.5)* | 58.5(49.8 to 67.3)* | 6.6(5.1 to 8.7)* | 49.6(40.7 to 58.5)* |
Leflunomide | ||||||
No (194) | 8.8(7.7 to 9.9) | 12.9(8.2 to 17.6) | 49.2(39.1 to 61.9)* | 56.7(49.7 to 63.7)* | 5.6(4.6 to 6.8)* | 50.5(43.5 to 57.6)* |
Yes (146) | 7.1(6.3 to 7.9)* | 8.3(3.8 to 12.7) | 71.3(53.5 to 95.1)* | 64.8(57.0 to 72.6)* | 10.1(7.6 to 13.4)* | 57.2(49.1 to 65.3)* |
Anti-TNF | ||||||
No (293) | 8.1(7.2 to 8.9) | 11.2(7.4 to 15.0) | 55.5(45.1 to 68.3)* | 58.8(52.9 to 64.8)* | 6.8(5.8 to 8.3)* | 51.0(45.0 to 57.0)* |
Yes (47) | 7.5(6.1 to 9.3) | 8.7(0.5 to 16.9) | 71.9(45.4 to 114.1)* | 67.4(53.7 to 81.1)* | 9.6(5.4 to 8.1)* | 67.4(53.7 to 81.1) |
Data are expressed in percentages or value (95% CI).
Anti-TNF agents adalimumab, infliximab or etanercept; medications prescribed to less than 10% of the patients were not included. GMT significantly increased in controls, RA patients and all the subsets.
↵* p <0.05, subsets compared with control group;
↵† p<0.05, comparison with or without the specific medication within a group.
Factor increase in GMT after vaccination.
GMT, geometric mean titre; RA, rheumatoid arthritis; RF, rheumatoid factor; TNF, tumour necrosis factor.