Table 3

Independent predictors of increase in DAS to greater than 2.4 with restart of infliximab (multivariable model)

HR (95% CI)HR (95% CI) after adjustment*
SE positive3.5 (1.2 to 10.1)3.7 (1.3 to 10.6)
Smoking positive2.4 (1.3 to 4.6)2.1 (1.1 to 4.2)
Treatment duration ≥18 months2.8 (1.3 to 6.1)2.4 (1.1 to 5.4)
Delayed treatment infliximabNA1.8 (0.9 to 3.7)
  • * Model including treatment timing.

  • DAS, disease activity score; SE, shared epitope.