Table 3

SNPs significantly associated with response to MTX (p<0.05) in UK CHARMS dataset

SNPGeneChromosomePositionMinor alleleMajor alleleMAF NRMAF ACR-Ped70OR (95% CI)p Trend
rs12995526ATIC2215906216CT0.570.421.79 (1.07 to 3.00)0.02
rs4673990ATIC2215914298GA0.480.351.69 (1.01 to 2.83)0.04
rs2295553ITPA203132134CT0.530.391.73 (1.03 to 2.89)0.05
  • ACR, American College of Rheumatology; CHARMS, CHildhood Arthritis Response to Medication Study; MAF, minor allele frequency; NR, non-responder; SNP, single nucleotide polymorphism.