Baseline characteristics and predictors of target knee replacement—univariate analyses
| Knee replacement | If p value <0.05 | ||||
|---|---|---|---|---|---|
| Yes (n=18) | No (n=105) | p Value* | OR | (95% CI) | |
| Male, % (no.) | 44% (8) | 34% (36) | 0.408 | ||
| Age (years), mean (SD) | 63.5 (6.1) | 59.8 (8.4) | 0.076 | ||
| BMI (kg/m2), mean (SD) | 31.9 (3.9) | 32.1 (6.4) | 0.919 | ||
| WOMAC, mean (SD) | |||||
| Baseline pain | 52.8 (10.9) | 57.6 (11.4) | 0.105 | ||
| Stiffness | 62.2 (19.3) | 62.2 (17.9) | 0.999 | ||
| Function | 54.4 (17.1) | 55.2 (16.0) | 0.839 | ||
| Total | 54.7 (14.3) | 56.3 (13.7) | 0.650 | ||
| CRP biomarker (mg/l), mean (SD) | 13.7 (12.7) | 7.3 (11.6) | 0.049 | 1.035 | (1.000 to 1.071) |
| Treatment effect, % (no) | 0.232 | ||||
| Licofelone | 39% (7) | 54% (57) | |||
| Naproxen | 61% (11) | 46% (48) | |||
| Joint space width, mean (SD) | 1.9 (2.0) | 3.5 (1.7) | 0.0008 | 0.579 | (0.420 to 0.797) |
| MRI cartilage volume (mm3), mean (SD) | |||||
| Medial compartment | 5292 (1499) | 5736 (1672) | 0.291 | ||
| Lateral compartment | 6401 (1948) | 6230 (1718) | 0.701 | ||
| Global knee | 11693 (3247) | 11966 (3180) | 0.736 | ||
| Meniscal lesion, % (no) | |||||
| Lateral tear | 83% (15) | 65% (68) | 0.132 | ||
| Severe lateral tear | 22% (4) | 22% (23) | 0.976 | ||
| Medial tear | 100% (18) | 83% (87) | 0.072† | ||
| Severe medial tear | 78% (14) | 38% (40) | 0.004 | 5.687 | (1.750 to 18.490) |
| Medial extrusion | 72% (13) | 39% (41) | 0.013 | 4.058 | (1.346 to 12.233) |
| BML score, mean (SD) | |||||
| Medial plateau | 1.8 (1.3) | 0.7 (1.0) | 0.0003 | 2.201 | (1.434 to 3.377) |
| Medial compartment | 4.2 (3.2) | 1.5 (2.0) | 0.0001 | 1.484 | (1.213 to 1.815) |
| Lateral compartment | 0.6 (1.2) | 0.4 (1.2) | 0.623 | ||
| Femoropatellar compartment | 0.8 (1.3) | 1.2 (1.8) | 0.379 | ||
| Global knee | 5.6 (4.7) | 3.1 (3.0) | 0.010 | 1.196 | (1.043 to 1.370) |