Table 3

Pooled analysis38 of response rates for autoantibody positive and negative patients from the MIRROR23 and SERENE24 studies

Week 24Week 48
SeropositiveSeronegativeSeropositiveSeronegative
ACR responses (n)514106506101
ACR20 (%)62.3*50.971.1*51.5
ACR50 (%)32.7*19.844.9**22.8
ACR70 (%)12.15.720.9*6.9
EULAR outcomes (n)507105496101
EULAR response (%)74.8*62.984.3*72.3
Mean change DAS28−1.97**−1.50−2.48***−1.72
DAS28 categories (n)510105499101
Low disease (%)16.910.526.5*12.9
DAS28 remission (%)10.64.813.25.9
  • * p<0.05,

  • ** p<0.001,

  • *** p<0.0001 vs seronegative.

  • ACR, American College of Rheumatology; DAS28, disease activity score 28; EULAR, European League Against Rheumatism.