Table 2

Variable 2-year change and risk of target knee replacement—univariate analyses

Knee replacementIf p value <0.05
Yes (n=18)No (n=105)p Value*OR(95% CI)
WOMAC, mean (SD)
 Total−11.6 (28.9)−27.7 (23.6)0.0261.027(1.003 to 1.051)
 Pain−11.4 (26.9)−28.8 (24.3)0.0091.028(1.007 to 1.049)
 Stiffness−17.4 (32.3)−30.5 (26.5)0.069
 Function−9.7 (29.7)−26.8 (24.5)0.0231.027(1.004 to 1.050)
CRP biomarker (mg/l), mean (SD)−28.9 (52.8)−4.5 (76.6)0.202
JSW reduction ≥7%, % (no)94% (17)52% (55)0.00915.454(1.984 to 120.388)
Cartilage volume, % (no)
 Medial compartment
  Reduction of at least 8%94% (17)48% (50)0.00518.700(2.401 to 145.669)
 Lateral compartment
  Reduction of at least 5%56% (10)51% (54)0.746
 Global knee
  Reduction of at least 7%78% (14)50% (52)0.0343.567(1.101 to 11.552)
BML score, mean (SD)
 Medial compartment0.4 (2.2)0.3 (1.2)0.801
 Lateral compartment0.1 (0.7)0.2 (0.7)0.449
 Femoropatellar compartment0.0 (0.4)0.3 (0.7)0.109
 Global knee0.5 (2.5)0.8 (1.6)0.493
  • * Logistic regression to predict a knee (target) replacement.

  • BML, bone marrow lesion; CI, confidence interval; CRP, C-reactive protein; JSW, joint space width; OR, odds ratio; WOMAC, Western Ontario and McMaster Universities osteoarthritis index.