Table 3

Validated composite measures and their cut-off points for different states of disease activity

Composite measure (number of components)Clinical Disease Activity Index2324(4)Simplified Disease Activity Index2324(5)Disease Activity Score based on 44 joint counts25(5)Disease Activity Score based on 28 joint counts26(5)
High disease activity>22>26>3.7>5.1
Moderate disease activity>10–22>11–26>2.4–3.7>3.2–5.1
Low disease activity>2.8–10>3.3–11≥1.6–2.4≥2.6–3.2
  • * American College of Rheumatology–European League Against Rheumatism preliminary definition of remission for clinical trials.15