Validated composite measures and their cut-off points for different states of disease activity
| Composite measure (number of components) | Clinical Disease Activity Index2324(4) | Simplified Disease Activity Index2324(5) | Disease Activity Score based on 44 joint counts25(5) | Disease Activity Score based on 28 joint counts26(5) |
|---|---|---|---|---|
| High disease activity | >22 | >26 | >3.7 | >5.1 |
| Moderate disease activity | >10–22 | >11–26 | >2.4–3.7 | >3.2–5.1 |
| Low disease activity | >2.8–10 | >3.3–11 | ≥1.6–2.4 | ≥2.6–3.2 |
| Remission | ≤2.8 | ≤3.3* | <1.6 | <2.6 |
↵* American College of Rheumatology–European League Against Rheumatism preliminary definition of remission for clinical trials.15