Modulation of FcγR expression during monocyte differentiation into macrophages*
| FcγRI | FcγRII | FcγRIII | ||||
|---|---|---|---|---|---|---|
| Monocytes | Macrophages | Monocytes | Macrophages | Monocytes | Macrophages | |
| Healthy controls (n=43) | 95.0 (80.9–98.8) | 52.2 (1.4–95.0) | 97.3 (82.5–99.8) | 97.8 (47.0–99.6) | 14.1 (0–57.2) | 85.9 (5.4–98.1) |
| p Value | 1.22e−14 | 0.87 | 2.57e−14 | |||
| RA patients (n=17) | 82.9 (40.8–98.5) | 76.2 (25.4–94.3) | 89 (47.6–99.5) | 97 (72.5–99.5) | 17.7 (5.8–30.2) | 92.2 (50.2–98.9) |
| p Value | 0.09 | 0.09 | 7.03e−07 | |||
↵* Values are the median (range) percentage of positive cells, evaluated by flow cytometry in the indicated number (n) of paired samples, p relates to the comparison between monocytes and macrophages.
FcγR, Fcγ receptor; RA, rheumatoid arthritis.