Observed prevalence (%) of radiographic HOA in men and women in the Framingham Offspring and Community cohorts
| Men (n=1001) | Women (n=1300) | |
|---|---|---|
| Radiographic HOA (≥1 joint(s)) | 47.9 (44.8 to 50.9) | 50.5 (47.8 to 53.3) |
| DIP (2nd–5th) OA | 28.7 (25.9 to 31.5) | 35.1 (32.5 to 37.7) |
| PIP (2nd–5th) OA | 13.5 (11.4 to 15.6) | 16.5 (14.5 to 18.6) |
| Thumb IP OA | 13.0 (10.9 to 15.1) | 15.8 (13.9 to 17.8) |
| MCP (1st–5th) OA | 11.9 (9.9 to 13.9) | 6.8 (5.5 to 8.2) |
| Thumb base OA | 30.3 (27.4 to 33.1) | 32.9 (30.3 to 35.4) |
| Wrist OA | 1.7 (0.9 to 2.5) | 1.0 (0.5 to 1.5) |
| One joint group with HOA | 20.9 (18.4 to 23.4) | 21.5 (19.2 to 23.7) |
| Two joint groups with HOA | 12.6 (10.5 to 14.6) | 12.5 (10.7 to 14.3) |
| Three or more joint groups with HOA | 14.4 (12.2 to 16.6) | 16.5 (14.5 to 18.6) |
| Radiographic HOA (≥2 joints) | 35.7 (32.7 to 38.6) | 38.2 (35.6 to 40.9) |
| Symptomatic HOA (≥1 joint(s)) | 8.2 (6.5 to 10.0) | 15.9 (13.9 to 17.9) |
| Erosive HOA (≥1 joint(s)) | 3.6 (2.4 to 4.7) | 9.8 (8.2 to 11.4) |
| Total KL score (all hand joints) | 6.3 (2, 0–9) | 8.2 (3, 0–11) |
| HOA joints (KLG≥2) | 2.0 (0, 0–3) | 2.7 (1, 0–3) |
| Erosive joints* | 3.8 (2.5, 1–5) | 3.9 (3, 1–6) |
| Symptomatic HOA joints† | 3.1 (2, 1–3) | 3.4 (2, 1–4) |
Data presented as % (95% CI), except for total KL score and number of affected joints presented as mean (median, interquartile range).
↵* In subjects with erosive HOA.
↵† In subjects with symptomatic HOA.
DIP, distal interphalangeal; HOA, hand osteoarthritis; IP, interphalangeal; KL, Kellgren and Lawrence; KLG, Kellgren–Lawrence grade; MCP, metacarpophalangeal; OA, osteoarthritis; PIP, proximal interphalangeal.