Table 2

Composition of groups of patients in study part II

Group AGroup BGroup CGroup C1Group C2
No of patients272228425173252
Mean age (SD)62.8 (11.8)58.4 (15.4)56.0 (16.8)58.3 (17.8)54.5 (16.0)
Sex (M/F)72/20072/156118/30763/11055/197
Cryo type I (%)5 (1.8)1 (0.4)
Cryo type II (%)194 (71.3)40 (17.5)
Cryo type III (%)32 (11.8)110 (48.2)
Cryo not typifiable (%)41 (15.1)77 (33.8)
Rheumatoid factor positivity (%)85.846.325.212.433.9
Low C4 (%)69.625.59.21.914.4
M component (%)82.727.23.72.84.4
Truly essential cryo (%)9 (3.3)7 (3.1)
HCV infection (%)*230 (84.6)153 (67.1)31 (7.3)31 (12.3)
SS (%)39 (14.4)34 (14.9)52 (12.2)52 (20.6)
Other CTDs (%)5 (1.8)30 (13.2)89 (20.9)89 (35.3)
Other vasculitis (%)173 (40.7)173 (100)
Other diseases(%)10 (3.7)8 (3.5)80 (18.8)80 (31.7)
  • * HCV infection could be also concomitant with SS or with other connective tissue diseases.

  • Systemic lupus erythematosus, systemic sclerosis, poly/dermatomyositis, undifferentiated connective tissue disease, mixed connective tissue disease, antiphospholipid syndrome.

  • In groups A and B, positivity for the hepatitis B virus surface antigen was noticed in 10 and in eight cases, respectively; see text for other diseases included in group C, to be differentiated from CV.

  • CTDs, connective tissue diseases; CV, cryoglobulinaemic vasculitis; F, female; HCV, hepatitis C virus; M, male; SS, Sjögren's syndrome.