Adjusted HRs (95% CIs) evaluating the risk of AMI associated with statin discontinuation stratified by timing of initiation of first statin, prior AMI, sex and age
| No. of AMI (in each stratum) | Adjusted HR for statin discontinuation (95% CI) | p Value for interaction* | |
|---|---|---|---|
| Initiation of first statin before RA | |||
| Yes | 78 | 2.13 (1.29 to 3.52) | 0.18 |
| No | 186 | 1.53 (1.06 to 2.21) | |
| Prior AMI | |||
| Yes | 68 | 1.55 (1.07 to 3.36) | 0.37 |
| No | 196 | 1.61 (1.16 to 2.22) | |
| Sex | |||
| Men | 136 | 1.79 (1.16 to 2.77) | 0.68 |
| Women | 128 | 1.51 (1.01 to 2.28) | |
| Age group | |||
| <65 years | 62 | 2.19 (1.20 to 3.99) | 0.40 |
| ≥65 years | 202 | 1.48 (1.05 to 2.09) | |
↵* p Value for the two-tailed Wald test of the interaction between a given stratification variable (shown in the first column) and statin discontinuation.
AMI, acute myocardial infarction; RA, rheumatoid arthritis.