Table 4

Adverse events

Double-blind 0–6 monthsDouble-blind/open-label 0–12 months
CSPlaceboCS/CSPlacebo/CS
Adverse eventn=35n=35n=32n=30
Total non-serious adverse events55384732
 Eye disorders1010
 Gastrointestinal disorders7775
 General (peripheral oedema)1211
 Infections12643
 Injury/poisoning6435
 Investigations (creatinine increased)1010
 Metabolism and nutrition0200
 Musculoskeletal13121313
 Nervous system4252
 Psychiatric disorders1213
 Renal and urinary disorders0100
 Skin disorders8070
 Surgical procedures1200
 Vascular disorders0020
Total serious adverse events1112
 Atrial fibrillation1000
 Cholecystitis0100
 Knee arthroplasty0011
 Syncope0001
  • CS, chondroitin sulphate (800 mg/day).