Multivariate regression models for BASDAI50 response and ASAS partial remission using variables with p<0.1 on univariate screening, stepwise selection and final selection of variables for both the ASSERT and the GO–RAISE datasets
ASSERT | GO–RAISE | Combined | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
All | Select | Final | All | Select | Final | All | Select | Final | Final category | |
Age | √, x | √, x | √, x | √, x | √, x | √, x | √, x | >/≤40 years | ||
BASDAI score | √, x | √, x | √, x | |||||||
BASFI score | √, x | √ | √, x | √, x | √, x | √, x | √, x | √, x | √, x | Tertiles |
BASMI score | √, x | x | √, x | √, x | ||||||
Cervical rotation | √, x | √, x | √, x | x | ||||||
Intermalleolar distance | √, x | √, x | √, x | |||||||
Tragus to wall distance | √, x | √, x | √, x | |||||||
Enthesitis score | √, x | √, x | √, x | x | √, x | √, x | √, x | √, x | 0/≥1 | |
CRP | √, x | √, x | √, x | √, x | √ | √, x | √, x | √, x | √, x | Tertiles |
PGA | √, x | √, x | √, x | |||||||
HLA-B27 | √, x | √, x | √, x | √ | √, x | √, x | √, x | √, x | +/− | |
Treatment | √, x | √, x | √, x | √, x | √, x | √, x | √, x | √, x | √, x | Anti-TNF/placebo |
R2 | 0.40, 0.34 | 0.36, 0.27 | 0.37, 0.27 | 0.27, 0.24 | 0.23, 0.18 | 0.24, 0.22 | 0.29, 0.26 | 0.27, 0.25 | 0.28, 0.24 | 0.32, 0.28 |
ROC–AUC (95% CI) | 0.83, 0.84 | 0.81, 0.80 | 0.82, 0.80 | 0.77, 0.78 | 0.75, 0.74 | 0.75, 0.77 | 0.78, 0.79 | 0.77, 0.79 | 0.77, 0.78 | 0.80 (0.76–0.83), 0.77 (0.73–0.82) |
R2 and the area under the receiver operating characteristics curve (ROC–AUC) are presented for the different models. √ represents Bath ankylosing spondylitis disease activity index (BASDAI) 50, x represents assessment of spondyloarthritis (ASAS) partial remission. R2 and ROC–AUC values are presented for BASDAI50 response, ASAS partial remission.
CRP, C-reactive protein; PGA, patient global assessment.