Genes associated with SLE
| Gene | Chromosome | Published p value | Published OR |
|---|---|---|---|
| BANK1 | 4q24 | 3.7×10−10 (EU) | 1.4 |
| BLK | 8p23.1 | 7.0×10−10 (EU) | 1.22 |
| C1q | 6p21.32 | ∼5–10 | |
| C2 | 6p21.32 | ∼5–10 | |
| C4A/B | 6p21.32 | ∼5–10 | |
| CRP | 1q23.2 | 6.41×10−7 (AA) | 0.49 |
| ETS1 | 11q24.3 | 1.77×10−25 (AS) | 1.37 |
| FcGR2A–FcGR3A | 1q23.2 | 6.78×10−7 (EU) | 0.74 |
| FcGR3B | 1q23.2 | 2.7×10−8 (EU) | – |
| HIC2-UBE2L3 | 22q11.21 | 7.53×10−8 (EU) | 1.22 |
| HLA-DR2 and DR3 | 6p21.32 | 1.71×10−52 (EU) | 2.36 |
| IKZF1 | 7p12.2 | 2.75×10−23 (AS) | 0.72 |
| IL-10 | 1q32.1 | 4.0×10−8 (EU) | 1.19 |
| IRAK1, MECP2 | Xq28 | 1.2×10−8 (EU, AS) | 1.39 |
| IRF5 | 7q32 | 4.4×10−16 (EU) | 1.45 |
| ITGAM–ITGAX | 16p11.2 | 1.61×10−23 (EU) | 1.62 |
| JAZF1 | 7p15.2 | 1.5×10−9 (EU) | 1.19 |
| KIAA1542/PHRF1 | 11p15.5 | 3.0×10−10 (EU) | 0.78 |
| LRRC18-WDFY4 | 10q11.22 | 7.22×10−12 (AS) | 1.24 |
| LYN | 8q12.1 | 5.4×10−9 (EU) | 0.77 |
| NMNAT2 | 1q25 | 1.08×10−7 (EU) | 0.85 |
| PRDM1, ATG5 | 6q21 | 1.74×10−8 (EU) | 1.19 |
| PTPN22 | 1p13 | 9×10−5 (EU) | 1.4 |
| PTTG1 | 5q33.3 | – | – |
| PXK | 3p14.3 | 7.10×10−9 (EU) | 1.25 |
| RASGRP3 | 2p22.3 | 1.3×10−15 (AS) | 0.7 |
| SLC15A4 | 12q24.32 | 1.77×10−11 (AS) | 1.26 |
| STAT1, STAT4 | 2q32.3 | 1.9×10−9 (EU) | 1.55 |
| TNFAIP3 | 6q23.3 | 2.9×10−12 (EU) | 2.3 |
| TNFSF4 | 1q25.1 | 6.08×10−7 (EU) | – |
| TNIP1 | 5q33.1 | 3.8×10−13 (EU) | 1.27 |
| TREX1 | 3p21.31 | 4.1×10−7 (EU) | ∼25 |
| UHRF1BP1 | 6p21.31 | 2.22×10−8 (EU) | 1.17 |
| XKR6 | 8p23.1 | 2.51×10−11 (EU) | 1.23 |
AA, African-American; AS, Asian; EU, European; SLE, systemic lupus erythematosus.