Table 2

Associations between baseline and 1-year time-integrated measures of inflammation and 3-year change in radiographic damage (univariate linear regression analyses)

	Independent variables: baseline measures			Independent variables: 12 months AUC of inflammatory markers
	β (95% CI)	R²	p Value	β (95% CI)	R²	p Value
Baseline characteristics
Female	−0.36 (−0.96 to 0.25)	0.02	0.24
Age	−0.002 (−0.02 to 0.02)	0.001	0.82
Anti-CCP positivity	0.50 (−0.16 to 1.15)	0.04	0.13
Clinical measures of disease activity
28-SJC	0.03 (−0.03 to 0.08)	0.01	0.31	0.01 (−0.001 to 0.02)	0.06	0.07
28-TJC	−0.01 (−0.05 to 0.03)	0.004	0.57	−0.002 (−0.01 to 0.005)	0.01	0.56
DAS28	0.14 (−0.05 to 0.32)	0.03	0.15	0.02 (−0.01 to 0.05)	0.03	0.19
Serological markers of inflammation
ESR	0.02 (0.01 to 0.04)	0.09	0.01^†	0.004 (0.001 to 0.01)	0.11	0.02^†
CRP	0.01 (−0.001 to 0.03)	0.05	0.06	0.01 (0.001 to 0.01)	0.09	0.03^†
MRI measures of inflammation
MRI synovitis	0.14 (0.01 to 0.26)	0.06	0.03^†	0.03 (0.01 to 0.05)	0.13	0.01^†
MRI bone marrow oedema	0.06 (0.02 to 0.10)	0.08	0.01^†	0.01 (0.004 to 0.02)	0.15	0.004^†
MRI tenosynovitis	−0.02 (−0.09 to 0.05)	0.01	0.54	0.005 (−0.01 to 0.02)	0.01	0.43

↵† p≤0.05.
28-SJC, 28-swollen joint count; 28-TJC, 28-tender joint count; anti-CCP, anti-citrullinated protein antibodies; AUC, area under the curve; CRP, C reactive protein; DAS28, disease activity score based on 28 joint counts; ESR, erythrocyte sedimentation rate; R², fraction of explained variance; vdHSS, van der Heijde Sharp score.