Comparison of cardiovascular risk markers across three patient categorisations†
| Cohorts | Anti-CCP positive (n=55) | Anti-CCP negative (n=51) | p Value | Joint erosions >median (n=54) | Joint erosions ≤median (n=53) | p Value | Extra-articular manifestations (n=13) | No extra-artarticular manifestations (n=100) | p Value |
|---|---|---|---|---|---|---|---|---|---|
| Soluble biomarkers | |||||||||
| CRP (mg/l) | 9.05 (1.71) | 5.26 (1.82) | 0.06 | 9.73 (2.12) | 8.67 (2.05) | 0.34 | 16.82 (3.45) | 4.88 (0.98) | <0.000* |
| Total cholesterol (mmol/l) | 5.20 (0.16) | 5.47 (0.17) | 0.22 | 5.12 (0.17) | 5.60 (0.17) | 0.03* | 5.18 (0.31) | 5.62 (0.09) | 0.16 |
| HDL cholesterol (mmol/l) | 1.66 (0.08) | 1.60 (0.09) | 0.55 | 1.59 (0.08) | 1.67 (0.09) | 0.46 | 1.69 (0.14) | 1.65 (0.04) | 0.79 |
| Atherogenic index | 3.45 (0.15) | 3.72 (0.16) | 0.17 | 3.35 (0.17) | 3.85 (0.16) | 0.02* | 3.34 (0.31) | 3.68 (0.09) | 0.27 |
| InNT-proBNP (pmol/l) | 2.43 (0.12) | 2.27 (0.13) | 0.30 | 2.49 (1.26) | 2.15 (1.23) | 0.03* | 2.53 (0.26) | 2.19 (0.08) | 0.19 |
| Peripheral biomarkers | |||||||||
| RHI | 2.13 (0.10) | 2.28 (0.11) | 0.30 | 2.06 (0.11) | 2.30 (0.11) | 0.08 | 2.05 (0.18) | 2.17 (0. | 0.44 |
| Brachial systolic pressure (mm Hg) | 133 (2.4) | 133 (2.4) | 132 (2.6) | 135 (2.5) | 0.28 | 136 (4.8) | 123 (1.3) | 0.20 | |
| Central biomarkers | |||||||||
| PWV | 8.02 (0.19) | 8.09 (0.21) | 0.77 | 7.88 (0.22) | 8.24 (0.20) | 0.18 | 8.38 (0.35) | 7.82 (0.10) | 0.12 |
| AIx | 22.84 (1.33) | 22.55 (1.43) | 0.87 | 23.86 (1.39) | 22.98 (1.31) | 0.61 | 23.17 (2.44) | 19.74 (0.71) | 0.17 |
| Central systolic pressure (mm Hg) | 124 (2.5) | 124 (2.7) | 0.99 | 122 (2.7) | 125 (2.5) | 0.36 | 125 (4.7) | 120 (1.4) | 0.33 |
| IMT (mm) | 0.74 (0.02) | 0.75 (0.02) | 0.74 | 0.75 (0.02) | 0.76 (0.02) | 0.55 | 0.73 (0.04) | 0.74 (0.01) | 0.66 |
| Composite score | |||||||||
| Framingham | 9.99 (1.06) | 9.54 (1.17) | 0.78 | 10.96 (0.96) | 12.29 (0.92) | 0.26 | 8.58 (1.69) | 10.54 (0.40) | 0.25 |
| SCORE | 3.42 (0.29) | 9.3.23 (0.32) | 0.64 | 3.77 (0.32) | 3.21 (0.30) | 0.15 | 2.60 (0.69) | 2.98 (0.17) | 0.59 |
Estimated marginal mean (SE) presented with adjustments for age and sex.
↵* p<0.05.
↵† The following three categorisations were compared: anti-CCP positive vs negative; joint erosions >median vs ≤median joint erosions; and presence of extra-articular manifestations vs no extra-articular manifestations.
AIx, augmentation index; CRP, high sensitivity C reactive protein; Framingham, Framingham risk score; HDL cholesterol, high density lipoprotein; IMT, intima-median thickness; lnNT-proBNP, natural logarithm of N-terminal pro-brain natriuretic peptide; PWV, pulse wave velocity; RHI, reactive hyperemia index; SCORE, European Society of Cardiology SCORE risk calculator.