Table 3

Comparison of cardiovascular risk markers across three patient categorisations

CohortsAnti-CCP positive (n=55)Anti-CCP negative (n=51)p ValueJoint erosions >median (n=54)Joint erosions ≤median (n=53)p ValueExtra-articular manifestations (n=13)No extra-artarticular manifestations (n=100)p Value
Soluble biomarkers
 CRP (mg/l)9.05 (1.71)5.26 (1.82)0.069.73 (2.12)8.67 (2.05)0.3416.82 (3.45)4.88 (0.98)<0.000*
 Total cholesterol (mmol/l)5.20 (0.16)5.47 (0.17)0.225.12 (0.17)5.60 (0.17)0.03*5.18 (0.31)5.62 (0.09)0.16
 HDL cholesterol (mmol/l)1.66 (0.08)1.60 (0.09)0.551.59 (0.08)1.67 (0.09)0.461.69 (0.14)1.65 (0.04)0.79
 Atherogenic index3.45 (0.15)3.72 (0.16)0.173.35 (0.17)3.85 (0.16)0.02*3.34 (0.31)3.68 (0.09)0.27
 InNT-proBNP (pmol/l)2.43 (0.12)2.27 (0.13)0.302.49 (1.26)2.15 (1.23)0.03*2.53 (0.26)2.19 (0.08)0.19
Peripheral biomarkers
 RHI2.13 (0.10)2.28 (0.11)0.302.06 (0.11)2.30 (0.11)0.082.05 (0.18)2.17 (0.0.44
 Brachial systolic pressure (mm Hg)133 (2.4)133 (2.4)132 (2.6)135 (2.5)0.28136 (4.8)123 (1.3)0.20
Central biomarkers
 PWV8.02 (0.19)8.09 (0.21)0.777.88 (0.22)8.24 (0.20)0.188.38 (0.35)7.82 (0.10)0.12
 AIx22.84 (1.33)22.55 (1.43)0.8723.86 (1.39)22.98 (1.31)0.6123.17 (2.44)19.74 (0.71)0.17
 Central systolic pressure (mm Hg)124 (2.5)124 (2.7)0.99122 (2.7)125 (2.5)0.36125 (4.7)120 (1.4)0.33
 IMT (mm)0.74 (0.02)0.75 (0.02)0.740.75 (0.02)0.76 (0.02)0.550.73 (0.04)0.74 (0.01)0.66
Composite score
 Framingham9.99 (1.06)9.54 (1.17)0.7810.96 (0.96)12.29 (0.92)0.268.58 (1.69)10.54 (0.40)0.25
 SCORE3.42 (0.29)9.3.23 (0.32)0.643.77 (0.32)3.21 (0.30)0.152.60 (0.69)2.98 (0.17)0.59
  • Estimated marginal mean (SE) presented with adjustments for age and sex.

  • * p<0.05.

  • The following three categorisations were compared: anti-CCP positive vs negative; joint erosions >median vs ≤median joint erosions; and presence of extra-articular manifestations vs no extra-articular manifestations.

  • AIx, augmentation index; CRP, high sensitivity C reactive protein; Framingham, Framingham risk score; HDL cholesterol, high density lipoprotein; IMT, intima-median thickness; lnNT-proBNP, natural logarithm of N-terminal pro-brain natriuretic peptide; PWV, pulse wave velocity; RHI, reactive hyperemia index; SCORE, European Society of Cardiology SCORE risk calculator.