SLE neuropsychiatric events (model A; more stringent) | SLE neuropsychiatric events (model B; less stringent) | Non-SLE neuropsychiatric events | Total neuropsychiatric events | |||||
---|---|---|---|---|---|---|---|---|
Event types | # | % | # | % | # | % | # | % |
Headache | 0 | 0 | 0 | 0 | 437 | 66 | 437 | 48 |
Mood disorders | 34 | 24 | 77 | 30 | 105 | 16 | 182 | 20 |
Seizure disorders | 12 | 9 | 22 | 9 | 4 | 1 | 26 | 3 |
Cognitive dysfunction | 14 | 10 | 37 | 15 | 26 | 4 | 63 | 7 |
Anxiety disorder | 0 | 0 | 0 | 0 | 58 | 9 | 58 | 6 |
Cerebrovascular disease | 20 | 14 | 31 | 12 | 0 | 0 | 31 | 3 |
Acute confusional state | 1 | 1 | 2 | 1 | 4 | 1 | 6 | 1 |
Polyneuropathy | 9 | 6 | 15 | 6 | 16 | 2 | 31 | 3 |
Mononeuropathy | 21 | 15 | 31 | 12 | 0 | 0 | 31 | 3 |
Neuropathy, cranial | 12 | 9 | 12 | 5 | 4 | 1 | 16 | 2 |
Psychosis | 1 | 1 | 2 | 1 | 0 | 0 | 2 | <0.5 |
Myelopathy | 8 | 6 | 14 | 6 | 0 | 0 | 14 | 2 |
Movement disorder | 1 | 1 | 2 | 1 | 2 | <0.5 | 4 | <0.5 |
Aseptic meningitis | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Demyelinating syndrome | 3 | 2 | 5 | 2 | 0 | 0 | 5 | 1 |
Guillain–Barré syndrome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Autonomic disorder | 2 | 1 | 2 | 1 | 0 | 0 | 2 | <0.5 |
Plexopathy | 1 | 1 | 1 | 0 | 2 | 0 | 3 | <0.5 |
Myasthenia gravis | 0 | 0 | 1 | <0.5 | 0 | 0 | 1 | <0.5 |
Total (%) neuropsychiatric events | 139 | 15 | 254 | 28 | 658 | 72 | 912 | 100 |
Attribution model A, neuropsychiatric events that had their onset within the enrolment window and had no ‘exclusions’ or ‘associations’ and were not one of the neuropsychiatric events identified by Ainiala et al18 were attributed to systemic lupus erythematosus (SLE); Attribution model B, neuropsychiatric events that had their onset within 10 years of the diagnosis of SLE and were still present within the enrolment window and had no ‘exclusions’ and were not one of the neuropsychiatric events identified by Ainiala et al18 were attributed to SLE.