Table 1

Descriptive statistics of study samples included, number of cases and controls for new and published studies and OR for the GDF5 rs143383 T allele

New dataPublished data
Rotterdam study IIIEstonian knee osteoarthritis studyHertfordshire cohort plus Nottingham casesGenetics of osteoarthritis and lifestyleChingford studyTen studies from large-scale meta-analysis (*)
GDF5 association data fromThis studyThis studyThis studyThis study75
Country of originNetherlandsEstoniaUKUKUKEurope, China, Japan
EthnicityCaucasianCaucasianCaucasianCaucasianCaucasianAsian and Caucasian
No of knee osteoarthritis cases/controls151/158265/4271141/536867/758259/5095085 /8135
Knee osteoarthritis definitionTF K/L ≥2TF K/L ≥2TF or PF K/L ≥2 or TKRTKRTF K/L ≥2Mixed
Women %56695249100NA
BMI mean (SD)27.7 (4.7)28.1 (5.4)28.2 (5.1)29.3 (5.3)26.7 (4.7)NA
Age mean (SD)56.0 (5.5)47.1 (6.4)67.2 (7.4)66.5 (7.9)64.1 (6.0)NA
rs143383 T allele % in knee osteoarthritis/controls64.6/61.0%67.7/60.3%63.3/62.9%68.5/62.1%67.6/59.5%NA
OR (95% CI)1.16 (0.91 to 1.49)1.38 (0.93 to 2.04)1.02 (0.87 to 1.1.8)1.32 (1.14 to 1.53)1.42 (1.13 to 1.77)1.15 (1.09 to 1.22)
  • * Data for all studies, the summary statistics reported for each of the individual studies were used separately and are shown in figure 1.

  • BMI, body mass index; K/L, Kellgren–Lawrence radiographic grade; PF, patellofemoral; TF, tibiofemoral; TKR, total knee replacement; NA, not applicable because it refers to 10 different studies.