Threshold levels for remission in the RA core set measures according to the survey of committee members*
Highest level of the core set measure that would be compatible with remission | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
If it were the only measure assessed | If all other measures suggested remission | |||||||||
Core set measure | Mean ± SD | Minimum | Median | 80% | Maximum | Mean ± SD | Minimum | Median | 80% | Maximum |
TJC28 | 1.1 ± 1.3 | 0 | 1 | 2 | 6 | 2.6 ± 2.0 | 1 | 2 | 4 | 10 |
Full TJC (68 joints) | 1.6 ± 1.5 | 0 | 2 | 2 | 6 | 2.6 ± 2.0 | 1 | 2 | 4 | 10 |
SJC28 | 0.5 ± 0.9 | 0 | 0 | 1 | 4 | 1.3 ± 1.3 | 0 | 1 | 2 | 6 |
Full SJC (66 joints) | 0.6 ± 0.9 | 0 | 0 | 1 | 4 | 1.4 ± 1.2 | 0 | 1 | 2 | 6 |
ESR, mm/h | 21 ± 6 | 10 | 20 | 25 | 30 | 25 ± 6 | 20 | 25 | 30 | 40 |
CRP, mg/dl | 0.9 ± 0.4 | 0 | 1 | 1 | 2 | 1.1 ± 0.6 | 0 | 1 | 1.5 | 2 |
Pain, 0–10 scale | 1.3 ± 0.7 | 0 | 1 | 2 | 3 | 2.4 ± 1.3 | 1 | 2 | 3 | 6 |
PhGA, 0–10 scale | 1.0 ± 0.9 | 0 | 1 | 1 | 4 | 1.6 ± 1.0 | 0 | 2 | 2 | 4 |
PtGA, 0–10 scale | 1.2 ± 0.8 | 0 | 1 | 2 | 3 | 2.2 ± 1.3 | 0 | 2 | 3 | 6 |
HAQ, 0–3 scale | 0.7 ± 0.7 | 0 | 0.5 | 0.5 | 3 | 0.9 ± 0.8 | 0.2 | 0.6 | 1 | 3 |
↵* Twenty-seven committee members responded to the survey (25 experienced rheumatoid arthritis clinical researchers and 2 Patients).
80%, 80th percentile; CRP, C reactive protein; ESR, erythrocyte sedimentation rate; HAQ, Health Assessment Questionnaire; PhGA, physician/observer global assessment; PtGA, patient global assessment; RA, rheumatoid arthritis; SJC28, swollen joint count using 28 joints; TJC28, tender joint count using 28 joints.