The relationship between stringent measures of remission, imaging-detected synovitis and function and quality of life outcomes
| DAS28 | |||||
|---|---|---|---|---|---|
| Variable | <1.17 (n=32) | 1.17–1.70 (n=31) | 1.71–2.03 (n=32) | >2.03 (n=33) | Test result, p value |
| Disease duration | 108 (63–189) | 96 (60–180) | 78 (51–108) | 96 (66–132) | J–T=−1.10, p=0.272 |
| SJC28 | 0.0 (0.0–0) | 0 (0–1) | 0 (0–1) | 1 (0–2) | J–T=4.19, p<0.001 |
| TJC28 | 0 (0–0) | 0 (0–0) | 0 (0–0) | 1 (0–2) | J–T=6.40, p<0.001 |
| CRP | 0.0 (0.0–0.0) | 0.0 (0.0–5.0) | 5.0 (0.0–8.8) | 5.0 (0.0–7.5) | J–T=5.65, p<0.001 |
| HAQ | 0.31 (0.00–0.87) | 0.25 (0.00–1.12) | 0.25 (0.00–1.00) | 0.38 (0.00–1.21) | J–T=0.48, p=0.634 |
| RAQoL | 2.0 (0.0–5.8) | 2.0 (1.0–8.0) | 3.0 (0.0–12.0) | 4.0 (1.0–12.0) | J–T=1.85, p=0.064 |
| Total GS score | 3.0 (2.0–6.8) | 5.0 (2.0–7.0) | 2.0 (0.0–5.0) | 3.0 (2.0–7.5) | J–T=−0.36, p=0.719 |
| Total PD score | 1.0 (0.0–2.0) | 1.0 (0.0–2.0) | 0.0 (0.0–1.0) | 1.0 (0.0–2.5) | J–T=−0.03, p=0.980 |
| GS=0 and PD=0: n (%) | 3 (9.4) | 5 (16.1) | 11 (34.4) | 3 (9.1) | L×L χ2=0.30, p=0.582 |
| GS≤1 and PD≤1: n (%) | 17 (53.1) | 12 (38.7) | 23 (71.9) | 20 (60.6) | L×L χ2=1.96, p=0.161 |
| PD=0: n (%) | 15 (46.9) | 14 (45.2) | 22 (68.8) | 12 (36.4) | L×L χ2=0.05, p=0.816 |
| PD≤1: n (%) | 24 (75.0) | 23 (74.2) | 28 (87.5) | 26 (78.8) | L×L χ2=0.57, p=0.452 |
| Max PD n (%):0 | 15 (46.9) | 14 (45.2) | 22 (68.8) | 12(36.4) | L×L χ2=0.29, p=0.590 |
| 1 | 9 (28.1) | 9 (29.0) | 6 (18.8) | 14 (42.4) | |
| 2 | 6 (18.8) | 6 (19.4) | 3 (9.4) | 7 (21.2) | |
| 3 | 2 (6.3) | 2 (6.5) | 1 (3.1) | 0 (0.0) | |
| Joints PD n (%): 0 | 187/224 (83.5) | 185/217 (85.3) | 206/224 (92.0) | 187/231 (90.0) | NA |
| 1 | 27/224 (12.1) | 20/217 (9.2) | 13/224 (5.8) | 33/231 (14.3) | |
| 2 | 8/224 (3.6) | 10/217 (4.6) | 4/224 (1.8) | 11/231 (4.8) | |
| 3 | 2/224 (0.9) | 2/217 (0.9) | 1/224 (0.4) | 0/231 (0.0) | |
| SDAI | |||||
|---|---|---|---|---|---|
| Variable | <1.51 (n=32) | 1.51–2.90 (n=32) | 2.91–4.61 (n=32) | >4.61 (n=32) | Test result, p value |
| Disease duration | 96 (63–189) | 90 (48–183) | 90 (60–129) | 84 (63–129) | J–T=−0.81, p=0.421 |
| SJC28 | 0 (0–0) | 0 (0–0) | 0 (0–1) | 1 (0–4) | J–T=6.48, p<0.001 |
| TJC28 | 0 (0–0) | 0 (0–0) | 0 (0–1) | 0 (0–2) | J–T=5.38, p<0.001 |
| CRP | 0.0 (0.0–5.2) | 0.0 (0.0–5.0) | 5.0 (0.0–7.8) | 0.0 (0.0–0.0) | J–T=−0.10, p=0.919 |
| HAQ | 0.13 (0.00–0.47) | 0.38 (0.00–1.09) | 0.56 (0.00–1.44) | 0.38 (0.03–1.13) | J–T=1.63, p=0.103 |
| RAQoL | 1.0 (0.0–4.0) | 3.0 (1.0–9.8) | 5.0 (1.0–13.0) | 2.5 (1.0–9.0) | J–T=1.85, p=0.065 |
| Total GS score | 3.0 (0.3–7.8) | 4.0 (2.0–5.0) | 3.0 (1.0–7.0) | 4.0 (2.0–7.0) | J–T=1.13, p=0.260 |
| Total PD score | 0.0 (0.0–2.0) | 0.0 (0.0–2.0) | 0.5 (0.0–2.0) | 1.0 (0.0–2.0) | J–T=0.64, p=0.523 |
| GS=0 and PD=0: n (%) | 8 (25.0) | 5 (15.6) | 6 (18.8) | 3 (9.4) | L×L χ2=2.14, p=0.144 |
| GS ≤1 and PD ≤1: n (%) | 19 (59.4) | 17 (53.1) | 19 (59.4) | 17 (53.1) | L×L χ2=0.10, p=0.751 |
| PD=0: n (%) | 17 (53.1) | 17 (53.1) | 16 (50.0) | 13 (40.6) | L×L χ2=1.05, p=0.306 |
| PD ≤1: n (%) | 25 (78.1) | 26 (81.3) | 26 (81.3) | 24 (75.0) | L×L χ2=0.08, p=0.772 |
| Max PD n (%):0 | 17 (53.0) | 17 (53.1) | 16 (50.0) | 13 (40.6) | L×L χ2=0.34, p=0.558 |
| 1 | 8 (25.0) | 9 (28.0) | 10 (31.3) | 11 (34.4) | |
| 2 | 4 (12.5) | 6 (18.8) | 6 (18.8) | 6 (18.8) | |
| 3 | 3 (9.4) | 0 (0.0) | 0 (0.0) | 2 (6.3) | |
| Joints PD n (%): 0 | 188/224 (83.9) | 197/224 (87.9) | 189/224 (84.4) | 191/224 (85.3) | NA |
| 1 | 24/224 (10.7) | 19/224 (8.5) | 27/224 (12.1) | 23/224 (10.3) | |
| 2 | 9/224 (4.0) | 8/224 (3.5) | 8/224 (3.6) | 8/224 (3.6) | |
| 3 | 3/224 (1.3) | 0/224 (0.0) | 0/224 (0.0) | 2/224 (0.9) | |
Values are median (first–third quartile) unless otherwise indicated.
ACR rem, American College of Rheumatology remission; CRP, C-reactive protein; DAS28, disease activity score using the 28 joint count; GS, grey scale synovitis; HAQ, health assessment questionnaire score; J–T, standardised Jonckheere–Terpstra statistic; L×L, linear by linear test of association; Max PD, maximum PD score observed in any joint; PD, power Doppler signal; RAQoL, rheumatoid arthritis quality of life score; SDAI, simplified disease activity score, SJC, swollen joint count; TJC, tender joint count.